Details

Autor(en) / Beteiligte

• Huang, Gang
• Wang, Chang-Xi
• Zeng, Wen-Tao
• Fei, Ji-Guang
• Qiu, Jiang
• Deng, Su-Xiong
• Li, Jun
• Chen, Guo-Dong
• Fu, Qian
• Chen, Li-Zhong

Titel

Clinical feature and analysis on the clinical related factors of BK virus associated nephropathy

Ist Teil von

• Zhong hua yi xue za zhi, 2011-09, Vol.91 (34), p.2402-2406

Ort / Verlag

China

Erscheinungsjahr

2011

Quelle

MEDLINE

Beschreibungen/Notizen

• To determine the incidence of BK virus associated nephropathy (BKVAN) in renal-transplantation recipients, observe its histological features. A total of 137 renal allograft biopsy specimens collected at our hospital during December 1999 to January 2008 were analyzed by routine histologic examination, immunohistochemistry and transmission electron microscopy (TEM) to screen for BKV. The case records of involved recipients were accessed to know their clinical manifestations, diagnostic characteristic and treatment regimens at that time. And the 1-, 3-year graft survival rate were analyzed by Kaplan-Meier analysis. A total of 16 renal biopsy specimens (11.7%) were positive for BKV. Viral particales on the size of 35 - 40 nm were seen in the tubular epithelial cells of 3 biopsy specimens and 7 urinary sediment samples. The numbers of BKVAN recipients suffering acute rejection, using ALG/ATG/OKT3 and using FK506+MMF immunosuppressive protocol were 7, 7 and 10 respectively. In 14 cases of BKVAN, there was an elevat