Cancer letters, 2012-04, Vol.317 (2), p.207-217
2012
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- Autor(en) / Beteiligte
- Titel
- Ovarian cancer: Stat3, RhoA and IGF-IR as therapeutic targets
- Ist Teil von
- Cancer letters, 2012-04, Vol.317 (2), p.207-217
- Ort / Verlag
- Ireland: Elsevier Ireland Ltd
- Erscheinungsjahr
- 2012
- Quelle
- Elsevier ScienceDirect Journals
- Beschreibungen/Notizen
- Seeking to improve ovarian cancer therapy, we compared biological characteristics of the moderately-aggressive OVCAR-3 cell line with two highly aggressive ovarian cancer cell populations: the SK-OV-3 cell line, and HASCJ primary cells isolated from the ascitic fluid of a patient with FIGO stage IV ovarian cancer. Secretion of angiogenic factors was not discriminative, whereas cell invasion through Matrigel and vasculogenic mimicry were much greater in the more aggressive cells. Among 10 agents tested for their ability to decrease cancer cell aggressivity using these two models, inhibitors of Stat3, IGF-IR and Rho GTPase were found to be the most promising.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0304-3835eISSN: 1872-7980DOI: 10.1016/j.canlet.2011.11.026Titel-ID: cdi_proquest_miscellaneous_921142027
- Format
- –
- Schlagworte
- Aggressiveness, Angiogenesis Inhibitors - pharmacology, Angiogenesis Inhibitors - therapeutic use, animal ovaries, Antineoplastic Agents - pharmacology, Antineoplastic Agents - therapeutic use, Blotting, Western, Cancer cell invasion, cell invasion, Cell Line, Cell Line, Tumor, Chemotherapy, Drug Screening Assays, Antitumor - methods, Female, guanosinetriphosphatase, Hematology, Oncology and Palliative Medicine, Humans, IGF, IGF-IR, Medical research, Models, Biological, Ovarian cancer, ovarian neoplasms, Ovarian Neoplasms - drug therapy, Ovarian Neoplasms - metabolism, Ovarian Neoplasms - pathology, patients, Receptor, IGF Type 1 - metabolism, Rho, rhoA GTP-Binding Protein - metabolism, secretion, Signal Transduction - drug effects, Stat3, STAT3 Transcription Factor - metabolism, therapeutics, Tumor Cells, Cultured, Vasculogenic mimicry