Details

Autor(en) / Beteiligte

• Liu, Qicai
• Lin, Xinhua
• Liu, Jingfeng
• Liu, Ailin
• Gao, Feng

Titel

The −409 C/T Genotype of PRSS1 Protects Against Pancreatic Cancer in the Han Chinese Population

Ist Teil von

• Digestive diseases and sciences, 2012-02, Vol.57 (2), p.573-579

Ort / Verlag

Boston: Springer US

Erscheinungsjahr

2012

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Background and Aims The high mortality rate of pancreatic cancer is a bottleneck for further treatment with long-term efficacy. Thus, it is urgent to identify new methods to accurately predict the early onset of pancreatic cancer. We hypothesized that the different genotypes of cationic trypsinogen ( PRSS1 ) gene could confer susceptibility and/or resistance to pancreatic cancer in the Han Chinese population. Methods The genotypes of PRSS1 were determined in 154 patients with pancreatic cancer and in a control group of 520 healthy individuals of Han Chinese descent. Clinical information was obtained, single-nucleotide polymorphisms (SNPs) of the PRSS1 gene were analyzed by direct sequencing, and the distribution of the genotypes were tested for Hardy–Weinberg equilibrium. Odds ratios and 95% confidence intervals were calculated by logistic regression analysis to estimate the associations between the different genotypes or haplotypes and the risk of pancreatic cancer. Results Three SNPs (−409 C/T, −204 A/C, and c.486 C/T) were identified. A case-control analysis revealed a 0.118-fold (95% CI: 0.037–0.653), 0.842-fold (95% CI: 0.177–4.010), and 0.750-fold (95% CI: 0.519–1.085) change in risk of developing pancreatic cancer for individuals harboring these SNPs, respectively. The individuals with the −409 C/T genotype tended to have a reduced risk compared to those who carried the −409 T/T genotype. A protective effect was observed for the C −409 –A −204 –C 486 haplotype compared to the T −409 –A −204 –T 486 haplotype (OR = 0.115, 95% CI: 0.016–0.849) or compared to the T −409 –A −204 –C 486 haplotype (OR = 0.090, 95% CI: 0.012–0.667). Serum levels of trypsin in patients with the −409 C/T genotype were only one-fourth that of those with the −409 T/T genotype and only one-third that of the healthy controls. Conclusions The −409 C/T genotype of PRSS1 was reveled to be a protective factor against pancreatic cancer in the Han Chinese population.