Details

Autor(en) / Beteiligte

• Gao, Yun-Fang
• Wang, Jun
• Wang, Hui-Ping
• Feng, Ban
• Dang, Kai
• Wang, Qi
• Hinghofer-Szalkay, Helmut G.

Titel

Skeletal muscle is protected from disuse in hibernating dauria ground squirrels

Ist Teil von

• Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 2012-03, Vol.161 (3), p.296-300

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2012

Quelle

Elsevier ScienceDirect Journals

Beschreibungen/Notizen

• The purpose of this study is to test the hypothesis that muscle fibers are protected from undue atrophy in hibernating dauria ground squirrels ( Spermophilus dauricus, Brandt). Muscle mass, fiber cross sectional area (CSA, video analysis) and fiber type distribution (m-ATPase staining) were determined in extensor digitorum longus (EDL) muscle from non-hibernating control animals (Pre-H), from animals who hibernated for one (H1) or two (H2) months, and from animals 2–4 days after arousal (Post-H; N = 8 each). Muscle wet weight decreased less than body weight in hibernating animals, resulting in a steady increase in muscle-to-body mass ratio (+ 37% in Post-H compared to Pre-H, p < 0.001). In the Pre-H group, Type I (6.3 ± 2.0%) and II (93.7 ± 2.0%) fiber CSAs were 1719 ± 201 and 2261 ± 287 μm 2, respectively. There was a tendency (n.s.) of larger CSA of type I in hibernators compared to pre-H. In the Post-H group, fiber CSA and type distribution were not different from Pre-H. We are the first to report data on EDL fiber type distribution and confirm a protective effect that prevents muscle atrophy in spite of prolonged disuse during hibernation in dauria ground squirrels.