Details

Autor(en) / Beteiligte

• Yamagishi, Makoto
• Nakano, Kazumi
• Miyake, Ariko
• Yamochi, Tadanori
• Kagami, Yayoi
• Tsutsumi, Akihisa
• Matsuda, Yuka
• Sato-Otsubo, Aiko
• Muto, Satsuki
• Utsunomiya, Atae
• Yamaguchi, Kazunari
• Uchimaru, Kaoru
• Ogawa, Seishi
• Watanabe, Toshiki

Titel

Polycomb-Mediated Loss of miR-31 Activates NIK-Dependent NF-κB Pathway in Adult T Cell Leukemia and Other Cancers

Ist Teil von

• Cancer cell, 2012-01, Vol.21 (1), p.121-135

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2012

Quelle

Elsevier ScienceDirect Journals

Beschreibungen/Notizen

• Constitutive NF-κB activation has causative roles in adult T cell leukemia (ATL) caused by HTLV-1 and other cancers. Here, we report a pathway involving Polycomb-mediated miRNA silencing and NF-κB activation. We determine the miRNA signatures and reveal miR-31 loss in primary ATL cells. MiR-31 negatively regulates the noncanonical NF-κB pathway by targeting NF-κB inducing kinase (NIK). Loss of miR-31 therefore triggers oncogenic signaling. In ATL cells, miR-31 level is epigenetically regulated, and aberrant upregulation of Polycomb proteins contribute to miR-31 downregulation in an epigenetic fashion, leading to activation of NF-κB and apoptosis resistance. Furthermore, this emerging circuit operates in other cancers and receptor-initiated NF-κB cascade. Our findings provide a perspective involving the epigenetic program, inflammatory responses, and oncogenic signaling. ► Signature of miRNA expression in adult T cell leukemia is determined ► Loss of miR-31 activates NF-κB pathway via NIK upregulation in ATL cells ► Genetic and epigenetic reprogramming is responsible for miR-31 regulation ► A pathway involving Polycomb, miR-31, and NF-κB links to malignant phenotypes