Details

Autor(en) / Beteiligte

• Uthamalingam, Shanmugam, MD
• Gurm, Gagandeep S., MD
• Sidhu, Manavjot S., MD
• Verdini, Daniel J., MD
• Vorasettakarnkij, Yongkasem, MD
• Engel, Leif-Christopher, MD
• Blankstein, Ron, MD
• Mamuya, Wilfred S., MD
• Hoffman, Udo, MD
• Brady, Thomas J., MD
• Cury, Ricardo C., MD
• Ghoshhajra, Brian B., MD, MBA

Titel

Comparison of dual-source 64-slice adenosine stress CT perfusion with stress-gated SPECT-MPI for evaluation of left ventricular function and volumes

Ist Teil von

• Journal of cardiovascular computed tomography, 2012, Vol.6 (1), p.24-30

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2012

Quelle

MEDLINE

Beschreibungen/Notizen

• Background Evaluation of left ventricular (LV) volumes and ejection fraction (LVEF) represent important components of pharmacologic stress imaging with either myocardial CT perfusion (CTP) or gated single-photon emission CT (SPECT) myocardial perfusion imaging (SPECT-MPI). Objectives We compared measurements of left ventricular function and volumes obtained with CTP and SPECT-MPI. Methods Forty-seven patients (mean age, 62 ± 11 years; male, n = 39) underwent stress CTP and SPECT-MPI. LVEF (in %), end-systolic volume (ESV; in mL), and end-diastolic volume (EDV; in mL) derived from stress CTP images were compared with SPECT-MPI. Results Stress CTP was in good agreement with SPECT-MPI for quantification of LVEF ( r = 0.91), EDV ( r = 0.75), and ESV ( r = 0.83; all P < 0.001). The mean LVEF measured by stress CTP (66% ± 17%) was similar to SPECT-MPI (64% ± 15%). Similar values were also derived for mean EDV (123 ± 30 mL vs 120 ± 34 mL) and ESV (44 ± 28 mL vs 51 ± 34 mL) for CTP and SPECT-MPI, respectively. Good agreement was also shown between both techniques for the assessment of regional wall motion with identical wall motion scores in 95.3% of the segments (κ = 0.79). Conclusions LVEF and LV volume parameters as determined by dual-source 64-slice adenosine stress CTP show a high correlation with values obtained with stress-gated SPECT-MPI.