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Heterosynaptic enhancement of the excitability of hippocampal mossy fibers by long-range spill-over of glutamate
Hippocampus, 2012-02, Vol.22 (2), p.222-229
Uchida, Takeshi
Fukuda, Satoshi
Kamiya, Haruyuki
2012
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Uchida, Takeshi
Fukuda, Satoshi
Kamiya, Haruyuki
Titel
Heterosynaptic enhancement of the excitability of hippocampal mossy fibers by long-range spill-over of glutamate
Ist Teil von
Hippocampus, 2012-02, Vol.22 (2), p.222-229
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2012
Quelle
Wiley-Blackwell Full Collection
Beschreibungen/Notizen
Several classes of ionotropic receptors have been reported to depolarize the axonal membrane of hippocampal mossy fibers. Both kainate receptors and GABAA receptors are localized on axons and/or presynaptic terminals, and these receptors have been known to be activated by synaptically released glutamate and GABA which spill out from the synaptic clefts. However the relative contribution of these two receptors in modulating the excitability of mossy fiber axon was not reported so far. In this study, we revealed that glutamate spilled out from commissural/associational synapses evoked the facilitation of antidromic population spikes of mossy fibers. Increase in amplitude and decrease in latency of population spikes suggest that the number of recruited mossy fibers increases by depolarization of axonal membrane. Application of non‐NMDA receptor antagonist CNQX (10 μM) almost abolished this effect. TBOA (30 μM), an inhibitor of glutamate transporter, prolonged the duration of heterosynaptic facilitation. These results suggest that glutamate released from distant commissural/associational synapses spills out from synaptic cleft and activates the kainate receptors on the mossy fibers of CA3 region, and plays a major role in modulating presynaptic excitability than GABA. © 2010 Wiley Periodicals, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 1050-9631
eISSN: 1098-1063
DOI: 10.1002/hipo.20885
Titel-ID: cdi_proquest_miscellaneous_917159203
Format
–
Schlagworte
Animals
,
autoreceptor
,
Glutamic Acid - metabolism
,
heterosynaptic facilitation
,
kainate receptor
,
Mice
,
Mice, Inbred C57BL
,
Mossy Fibers, Hippocampal - metabolism
,
Organ Culture Techniques
,
Patch-Clamp Techniques
,
presynapse
,
Synapses - metabolism
,
Synaptic Transmission - physiology
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