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Cranial nerve, spinal root and plexus hypertrophy in chronic inflammatory demyelinating polyneuropathy
Ist Teil von
Practical Neurology, 2012-02, Vol.12 (1), p.68-69
Ort / Verlag
London: BMJ Publishing Group Ltd
Erscheinungsjahr
2012
Quelle
BMJ Journals Archiv - DFG Nationallizenzen
Beschreibungen/Notizen
Comment Although observed in a variety of other conditions including hereditary neuropathies, neurofibromatosis, lymphoma, Refsum's disease, leprosy and amyloidosis, chronic inflammatory demyelinating polyneuropathy is one of the commoner causes of hypertrophic neuropathy on MRI and has been reported to be present in 11-57% of patients. 1 2 The hypertrophy appears to be related to the duration of disease and is thought to be secondary to repeated demyelination and remyelination, with Schwann cell proliferation and onion-bulb formation leading to increased nerve volume. 2 The hypertrophic changes have been reported to correlate with the site of conduction block on electrophysiology but not with time from last relapse, type of therapy or disability status. 2 3 Gadolinium enhancement of the nerve roots, with or without hypertrophy, is indicative of blood-nerve barrier breakdown and may suggest clinically active disease. 3 Although rare, massive enlargement of the nerve roots may even cause spinal cord compression. 4 Acknowledgement: Reviewed by John Winer, Birmingham, UK.