Bioorganic & medicinal chemistry letters, 2012-01, Vol.22 (1), p.391-395
2012
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- Autor(en) / Beteiligte
- Titel
- Towards a modern definition of vitamin E—evidence for a quinone hypothesis
- Ist Teil von
- Bioorganic & medicinal chemistry letters, 2012-01, Vol.22 (1), p.391-395
- Ort / Verlag
- Amsterdam: Elsevier Ltd
- Erscheinungsjahr
- 2012
- Quelle
- Elsevier ScienceDirect Journals
- Beschreibungen/Notizen
- We report on the synthesis, biological and pharmacological activity of the tocoquinone natural product, α-tocopherol quinone (ATQ); an oxidative metabolite of α-tocopherol. ATQ is a potent cellular protectant against oxidative stress, whose biological activity is dependent upon its ability to undergo reversible two-electron redox cycling. ATQ is orally bioavailable, with a favorable pharmacokinetic profile and has demonstrated a beneficial clinical response in patients with Friedreich’s ataxia. ATQ is a member of a broader class of vitamin E derived quinone metabolites which may be ascribable in whole or in part to the activity of vitamin E.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0960-894XeISSN: 1464-3405DOI: 10.1016/j.bmcl.2011.10.117Titel-ID: cdi_proquest_miscellaneous_913316043
- Format
- –
- Schlagworte
- alpha-tocopherol, alpha-Tocopherol - metabolism, Animals, bioactive properties, Biological and medical sciences, chemistry, CHO Cells, Cricetinae, Dogs, Dose-Response Relationship, Drug, Drug Design, Fibroblasts - metabolism, Friedreich Ataxia - metabolism, Friedreich’s ataxia, Humans, Hydrolases - chemistry, Medical sciences, metabolites, Mice, Micronucleus Tests, Models, Chemical, NAD(P)H Dehydrogenase (Quinone) - metabolism, NQO1, Nutritional Sciences, Oxidation-Reduction, Oxidative Stress, patients, pharmacokinetics, Pharmacology. Drug treatments, Primary fibroblast, Quinone, Quinones - chemistry, Rats, Redox active, Vitamin E - analogs & derivatives, Vitamin E - chemistry, Vitamin E - metabolism, Vitamin E - pharmacology, Vitamin E metabolite