Details

Autor(en) / Beteiligte

• Chen, Jessie Z.-J.
• Sheehan, Penelope M.
• Brennecke, Shaun P.
• Keogh, Rosemary J.

Titel

Vessel remodelling, pregnancy hormones and extravillous trophoblast function

Ist Teil von

• Molecular and cellular endocrinology, 2012-02, Vol.349 (2), p.138-144

Ort / Verlag

Ireland: Elsevier Ireland Ltd

Erscheinungsjahr

2012

Link zum Volltext

Quelle

Elsevier ScienceDirect Journals Complete

Beschreibungen/Notizen

• ► Vessel remodelling in early human pregnancy requires trophoblast invasion. ► hCG, P4 and E2 are all found at high concentrations at the maternal–foetal interface. ► These hormones can control trophoblast movement and thus may regulate remodelling. ► We review the effects of these pregnancy hormones on trophoblast function. ► A role for these hormones in defective remodelling seen in pre-eclampsia is examined. During early human pregnancy, extravillous trophoblast (EVT) cells from the placenta invade the uterine decidual spiral arterioles and mediate the remodelling of these vessels such that a low pressure, high blood flow can be supplied to the placenta. This is essential to facilitate normal growth and development of the foetus. Defects in remodelling can manifest as the serious pregnancy complication pre-eclampsia. During the period of vessel remodelling three key pregnancy-associated hormones, human chorionic gonadotrophin (hCG), progesterone (P4) and oestradiol (E2), are found in high concentrations at the maternal–foetal interface. Potentially these hormones may control EVT movement and thus act as regulators of vessel remodelling. This review will discuss what is known about how these hormones affect EVT proliferation, migration and invasion during vascular remodelling and the potential relationship between hCG, P4, E2 and the development of pre-eclampsia.