Details

Autor(en) / Beteiligte

• Vlassenko, Andrei G.
• Mintun, Mark A.
• Xiong, Chengjie
• Sheline, Yvette I.
• Goate, Alison M.
• Benzinger, Tammie L. S.
• Morris, John C.

Titel

Amyloid-beta plaque growth in cognitively normal adults: Longitudinal [11C]Pittsburgh compound B data

Ist Teil von

• Annals of neurology, 2011-11, Vol.70 (5), p.857-861

Ort / Verlag

Hoboken: Wiley Subscription Services, Inc., A Wiley Company

Erscheinungsjahr

2011

Quelle

Wiley Online Library All Journals

Beschreibungen/Notizen

• Amyloid‐beta (Aβ) accumulation was evaluated with 2 [11C]Pittsburgh compound B (PiB) positron emission tomography scans about 2.5 years apart in 146 cognitively normal adults. Seventeen of 21 participants with initially elevated Aβ deposition demonstrated subsequent Aβ plaque growth (approximately 8.0% per year), and none reverted to a state of no Aβ deposits. Ten individuals converted from negative to positive PiB status, based on a threshold of the mean cortical binding potential, representing a conversion rate of 3.1% per year. Individuals with an ε4 allele of apolipoprotein E demonstrated increased incidence of conversion (7.0% per year). Our findings suggest that the major growth in Aβ burden occurs during a preclinical stage of Alzheimer disease (AD), prior to the onset of AD‐related symptoms. Ann Neurol 2011