Details

Autor(en) / Beteiligte

• Wen, Dan
• Zhou, Xian-Liang
• Li, Jian-Jun
• Luo, Fang
• Zhang, Lin
• Gao, Ling-Gen
• Wang, Lin-Ping
• Song, Lei
• Sun, Kai
• Zou, Yu-Bao
• Zhang, Chan-Na
• Hui, Ru-Tai

Titel

Plasma concentrations of interleukin-6, C-reactive protein, tumor necrosis factor-α and matrix metalloproteinase-9 in aortic dissection

Ist Teil von

• Clinica chimica acta, 2012-01, Vol.413 (1-2), p.198-202

Ort / Verlag

Netherlands: Elsevier B.V

Erscheinungsjahr

2012

Quelle

Access via ScienceDirect (Elsevier)

Beschreibungen/Notizen

• The role of inflammation in aortic dissection (AD) has not fully been investigated. We evaluated the potential relationships between interleukin-6 (IL-6), C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), and matrix metalloproteinase-9 (MMP-9) and AD. Plasma concentrations of IL-6, TNF-α, MMP-9 and CRP were determined in 64 acute AD patients, 42 patients with chronic AD, 98 patients with hypertension alone, and 96 healthy subjects. IL-6 concentrations were higher in acute AD than that in hypertension and healthy controls (10.98±2.38 vs. 3.79±1.56 and 3.32±1.60pg/ml, P<0.05, respectively). Increased CRP concentrations were found in acute AD compared with chronic AD and hypertension as well as healthy subjects (13.48±3.74 vs. 4.12±2.99, 1.62±0.65 and 1.12±0.35mg/l, P<0.001, respectively). Higher MMP-9 concentrations were detected in acute AD, chronic AD and hypertension compared with healthy controls (37.75±9.38, 55.78±6.41 and 31.03±7.94 vs. 21.24±7.28ng/ml, P<0.05, P<0.001 and P<0.05, respectively), and in the dead compared to the survived (107.29±9.38 vs. 86.80±7.93ng/ml, P<0.001) among acute AD patients. In acute AD, the time after onset had positive correlation with TNF-α (r=0.497, P=0.000), and negative correlation with CRP (r=−0.424, P=0.000). Plasma CRP levels decreased significantly when the onset time increased (P=0.013). Moreover, in the patients with acute AD who underwent surgery and stenting, plasma MMP-9 concentrations increased immediately after surgical treatment and stenting, and reached the peak values at 24h, then decreased at 1week (P<0.001). Our findings confirmed and extended previous studies that increased plasma inflammatory markers were significantly associated with AD. ► The role of inflammation in aortic dissection (AD) has not fully been investigated. ► IL-6, TNF-a, MMP-9, and CRP were compared among the four groups. ► Elevated plasma inflammatory markers were significantly associated with AD.