Molecular nutrition & food research, 2011-12, Vol.55 (12), p.1829-1840
2011
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- Autor(en) / Beteiligte
- Titel
- Long-term curcumin administration protects against atherosclerosis via hepatic regulation of lipoprotein cholesterol metabolism
- Ist Teil von
- Molecular nutrition & food research, 2011-12, Vol.55 (12), p.1829-1840
- Ort / Verlag
- Weinheim: WILEY-VCH Verlag
- Erscheinungsjahr
- 2011
- Quelle
- Wiley Online Library Journals Frontfile Complete
- Beschreibungen/Notizen
- Scope: Atherosclerosis is a major cause of cardiovascular disease caused by high cholesterol. Stains are widely prescribed to lower cholesterol levels, but natural dietary compounds may also be effective. Therefore, we studied the effect of the natural dietary compound curcumin on atherosclerosis and its underlying mechanisms based on plasma and hepatic lipid metabolism. Methods and results: LDLR−/− mice were fed a high‐cholesterol diet and treated with curcumin, lovastatin or control (n=10 per group) for 18 wk. Aortic arch sections revealed curcumin ameliorated early atherosclerotic lesions, lipid infiltration, ICAM‐1 and VCAM‐1 localization, similar to lovastatin treatment. Furthermore, curcumin lowered plasma cholesterol, triglycerides, LDL cholesterol and Apo B levels as well as CETP activity, while curcumin increased plasma HDL cholesterol and liver Apo A‐I expression, similar to lovastatin treatment. Curcumin caused transcriptional inhibition of HMG‐CoA reductase, independent of ACAT1 and ACAT2 expression. Hepatic PPARα and LXRα expression was upregulated by curcumin treatment. Hepatic complement factor D (Cfd) and systemic CRP levels, markers of immune complement pathway activation, were significantly reduced by curcumin treatment. Conclusion: Long‐term curcumin treatment lowers plasma and hepatic cholesterol and suppresses early atherosclerotic lesions comparable to the protective effects of lovastatin. The anti‐atherogenic effect of curcumin is mediated via multiple mechanisms including altered lipid, cholesterol and immune gene expression.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1613-4125eISSN: 1613-4133DOI: 10.1002/mnfr.201100440Titel-ID: cdi_proquest_miscellaneous_908738665
- Format
- –
- Schlagworte
- Acetyl-CoA C-Acetyltransferase - genetics, Acetyl-CoA C-Acetyltransferase - metabolism, Animals, Apolipoprotein A-I - genetics, Apolipoprotein A-I - metabolism, Apolipoproteins B - blood, Apolipoproteins B - drug effects, Atherosclerosis, Atherosclerosis - prevention & control, Biological and medical sciences, Cholesterol - metabolism, Cholesterol, Dietary, Cholesterol, HDL - blood, Cholesterol, HDL - drug effects, Cholesterol, LDL - blood, Cholesterol, LDL - drug effects, Curcumin, Curcumin - administration & dosage, Food industries, Fundamental and applied biological sciences. Psychology, Gene expression, HMG-CoA, Hydroxymethylglutaryl CoA Reductases - metabolism, Hydroxymethylglutaryl-CoA Reductase Inhibitors - metabolism, Intercellular Adhesion Molecule-1 - drug effects, Intercellular Adhesion Molecule-1 - metabolism, Lipid Metabolism - drug effects, Lipoproteins - metabolism, Liver - drug effects, Liver - metabolism, Liver X Receptors, Lovastatin, Lovastatin - administration & dosage, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Orphan Nuclear Receptors - genetics, Orphan Nuclear Receptors - metabolism, PPAR alpha - genetics, PPAR alpha - metabolism, Triglycerides - blood, Up-Regulation, Vascular Cell Adhesion Molecule-1 - drug effects, Vascular Cell Adhesion Molecule-1 - metabolism