Details

Autor(en) / Beteiligte

• Nicholls, Stephen J
• Ballantyne, Christie M
• Barter, Philip J
• Chapman, M. John
• Erbel, Raimund M
• Libby, Peter
• Raichlen, Joel S
• Uno, Kiyoko
• Borgman, Marilyn
• Wolski, Kathy
• Nissen, Steven E

Titel

Effect of Two Intensive Statin Regimens on Progression of Coronary Disease

Ist Teil von

• The New England journal of medicine, 2011-12, Vol.365 (22), p.2078-2087

Ort / Verlag

Waltham, MA: Massachusetts Medical Society

Erscheinungsjahr

2011

Quelle

MEDLINE

Beschreibungen/Notizen

• In this trial, intravascular ultrasonography was used to compare the effects of atorvastatin versus rosuvastatin on regression of coronary atherosclerosis. Both statins led to regression in two thirds of patients, with no significant difference between their effects. Randomized clinical trials have consistently shown that inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase (statins) reduce cardiovascular event rates. 1 – 9 The favorable effects of statins extend across a range of levels of low-density lipoprotein (LDL) cholesterol, with no apparent lower threshold for a benefit. 3 , 9 , 10 In parallel, imaging trials have shown that intensive statin regimens slow the progression of coronary atherosclerosis and may even result in disease regression in some patients. 11 , 12 Accordingly, guidelines for cardiovascular disease prevention have increasingly emphasized that lowering LDL cholesterol levels with statins is the primary goal of lipid-modulating therapy. 13 , 14 Available statins differ considerably . . .