Details

Autor(en) / Beteiligte

• Fedonin, G. G.
• Rakhmaninova, A. B.
• Korostelev, Yu. D.
• Laikova, O. N.
• Gelfand, M. S.

Titel

Machine learning study of DNA binding by transcription factors from the LacI family

Ist Teil von

• Molecular biology (New York), 2011-08, Vol.45 (4), p.724-679

Ort / Verlag

Dordrecht: SP MAIK Nauka/Interperiodica

Erscheinungsjahr

2011

Quelle

MEDLINE

Beschreibungen/Notizen

• We studied 1372 LacI-family transcription factors and their 4484 DNA binding sites using machine learning algorithms and feature selection techniques. The Naive Bayes classifier and Logistic Regression were used to predict binding sites given transcription factor sequences and to classify factor-site pairs on binding and non-binding ones. Prediction accuracy was estimated using 10-fold cross-validation. Experiments showed that the best prediction of nucleotide densities at selected site positions is obtained using only a few key protein sequence positions. These positions are stably selected by the forward feature selection based on the mutual information of factor-site position pairs.