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Tid1 functions as a tumour suppressor in head and neck squamous cell carcinoma
The Journal of pathology, 2009-11, Vol.219 (3), p.347-355
Chen, Chi-Yuan
Chiou, Shih-Hwa
Huang, Chih-Yang
Jan, Chia-Ing
Lin, Shu-Chun
Hu, Wen-Yuan
Chou, Shiu-Huey
Liu, Chung-Ji
Lo, Jeng-Fan
2009
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Chen, Chi-Yuan
Chiou, Shih-Hwa
Huang, Chih-Yang
Jan, Chia-Ing
Lin, Shu-Chun
Hu, Wen-Yuan
Chou, Shiu-Huey
Liu, Chung-Ji
Lo, Jeng-Fan
Titel
Tid1 functions as a tumour suppressor in head and neck squamous cell carcinoma
Ist Teil von
The Journal of pathology, 2009-11, Vol.219 (3), p.347-355
Ort / Verlag
Chichester, UK: John Wiley & Sons, Ltd
Erscheinungsjahr
2009
Quelle
MEDLINE
Beschreibungen/Notizen
Human tumourous imaginal disc (Tid1), a human homologue of the Drosophila tumour suppressor protein Tid56, is involved in multiple intracellular signalling pathways such as apoptosis, cell proliferation, and cell survival. Here, we investigated the anti-tumourigenic activity of Tid1 in head and neck squamous cell carcinoma (HNSCC) in vitro and in vivo. Firstly, the clinical association between Tid1 expression and progression of HNSCC was explored. It was found that expression of Tid1 was negatively associated with tumour status, recurrence, and survival prognosis using immunohistochemical analysis of primary HNSCC patient tumour tissue. Secondly, ectopic expression of Tid1 in HNSCC cells was shown to significantly inhibit cell proliferation, migration, invasion, anchorage-independent growth, and xenotransplantation tumourigenicity. Thirdly, we showed that overexpression of Tid1 attenuated EGFR activity and blocked the activation of AKT in HNSCC cells, which are known to be involved in the regulation of survival in HNSCC cells. On the other hand, ectopic expression of constitutively active AKT greatly reduced apoptosis induced by Tid1 overexpression. Together, these findings suggest that Tid1 functions as a tumour suppressor in HNSCC tumourigenesis. Copyright © 2009 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Sprache
Englisch
Identifikatoren
ISSN: 0022-3417
eISSN: 1096-9896
DOI: 10.1002/path.2604
Titel-ID: cdi_proquest_miscellaneous_907169171
Format
–
Schlagworte
Adult
,
Aged
,
AKT
,
AKT protein
,
Animals
,
Apoptosis
,
Apoptosis - physiology
,
Carcinoma, Squamous Cell - metabolism
,
Carcinoma, Squamous Cell - pathology
,
Carcinoma, Squamous Cell - physiopathology
,
Cell Adhesion - physiology
,
Cell migration
,
Cell Movement - physiology
,
Cell Proliferation
,
Cell survival
,
Cell Transformation, Neoplastic - metabolism
,
Cell Transformation, Neoplastic - pathology
,
Drosophila
,
EGFR
,
Epidermal growth factor receptors
,
Female
,
Head and neck cancer
,
Head and Neck Neoplasms - metabolism
,
Head and Neck Neoplasms - pathology
,
Head and Neck Neoplasms - physiopathology
,
HSP40 Heat-Shock Proteins - metabolism
,
HSP40 Heat-Shock Proteins - physiology
,
Humans
,
Imaginal discs
,
Intracellular signalling
,
Male
,
Mice
,
Mice, Nude
,
Middle Aged
,
Neoplasm Invasiveness
,
Neoplasm Staging
,
Neoplasm Transplantation
,
Phosphatidylinositol 3-Kinases - metabolism
,
Prognosis
,
Proto-Oncogene Proteins c-akt - metabolism
,
Receptor, Epidermal Growth Factor - metabolism
,
squamous cell carcinoma
,
Tid1
,
Tumor Cells, Cultured
,
Tumor Suppressor Proteins - metabolism
,
Tumor Suppressor Proteins - physiology
,
tumour suppressor
,
Xenografts
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