Internal Medicine, 2009, Vol.48(16), pp.1433-1435
2009
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- Autor(en) / Beteiligte
- Titel
- Successful Pregnancy in a Patient with Chronic Myeloid Leukemia under Treatment with Imatinib
- Ist Teil von
- Internal Medicine, 2009, Vol.48(16), pp.1433-1435
- Ort / Verlag
- Japan: The Japanese Society of Internal Medicine
- Erscheinungsjahr
- 2009
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Contraception is recommended during imatinib therapy based on the teratogenicity data in rats. However, patients may become pregnant and here we describe a successful pregnancy and labor without any congenital anomaly in a patient with chronic myeloid leukemia (CML) under treatment with imatinib. The patient had received imatinib for 53 months before she became pregnant, with a complete cytogenetic response achieved after 6 months of therapy and a major molecular response (MMR) after 28 months. CML was in MMR at discovery of pregnancy and the fetus had been exposed to imatinib for 5 weeks. Treatment was discontinued, but MMR persisted during gestation.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0918-2918, 1349-7235eISSN: 1349-7235DOI: 10.2169/internalmedicine.48.2084Titel-ID: cdi_proquest_miscellaneous_907165453
- Format
- –
- Schlagworte
- Benzamides, chronic myeloid leukemia, Female, Humans, imatinib, Imatinib Mesylate, Infant, Newborn, Leukemia, Myelogenous, Chronic, BCR-ABL Positive - diagnosis, Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy, Male, Piperazines - adverse effects, Piperazines - therapeutic use, Pregnancy, Pregnancy Complications, Neoplastic - diagnosis, Pregnancy Complications, Neoplastic - drug therapy, Pyrimidines - adverse effects, Pyrimidines - therapeutic use, Remission Induction - methods, Treatment Outcome, Young Adult