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Functional convergence of developmentally and adult-generated granule cells in dentate gyrus circuits supporting hippocampus-dependent memory
Hippocampus, 2011-12, Vol.21 (12), p.1348-1362
Stone, Scellig S.D.
Teixeira, Cátia M.
Zaslavsky, Kirill
Wheeler, Anne L.
Martinez-Canabal, Alonso
Wang, Afra H.
Sakaguchi, Masanori
Lozano, Andres M.
Frankland, Paul W.
2011
Details
Autor(en) / Beteiligte
Stone, Scellig S.D.
Teixeira, Cátia M.
Zaslavsky, Kirill
Wheeler, Anne L.
Martinez-Canabal, Alonso
Wang, Afra H.
Sakaguchi, Masanori
Lozano, Andres M.
Frankland, Paul W.
Titel
Functional convergence of developmentally and adult-generated granule cells in dentate gyrus circuits supporting hippocampus-dependent memory
Ist Teil von
Hippocampus, 2011-12, Vol.21 (12), p.1348-1362
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2011
Link zum Volltext
Quelle
Wiley Online Library Journals Frontfile Complete
Beschreibungen/Notizen
In the hippocampus, the production of dentate granule cells (DGCs) persists into adulthood. As adult‐generated neurons are thought to contribute to hippocampal memory processing, promoting adult neurogenesis therefore offers the potential for restoring mnemonic function in the aged or diseased brain. Within this regenerative context, one key issue is whether developmentally generated and adult‐generated DGCs represent functionally equivalent or distinct neuronal populations. To address this, we labeled separate cohorts of developmentally generated and adult‐generated DGCs and used immunohistochemical approaches to compare their integration into circuits supporting hippocampus‐dependent memory in intact mice. First, in the water maze task, rates of integration of adult‐generated DGCs were regulated by maturation, with maximal integration not occurring until DGCs were five or more weeks in age. Second, these rates of integration were equivalent for embryonically, postnatally, and adult‐generated DGCs. Third, these findings generalized to another hippocampus‐dependent task, contextual fear conditioning. Together, these experiments indicate that developmentally generated and adult‐generated DGCs are integrated into hippocampal memory networks at similar rates, and suggest a functional equivalence between DGCs generated at different developmental stages. © 2010 Wiley Periodicals, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 1050-9631
eISSN: 1098-1063
DOI: 10.1002/hipo.20845
Titel-ID: cdi_proquest_miscellaneous_905965459
Format
–
Schlagworte
Age Factors
,
Animals
,
Avoidance Learning - physiology
,
Conditioning, Classical
,
contextual fear conditioning
,
Convulsants - toxicity
,
Crosses, Genetic
,
Cytoskeletal Proteins - biosynthesis
,
Cytoskeletal Proteins - genetics
,
Dentate Gyrus - cytology
,
Dentate Gyrus - growth & development
,
Dentate Gyrus - pathology
,
Electric Stimulation
,
Entorhinal Cortex - physiology
,
Fear - physiology
,
Genes, fos - drug effects
,
learning
,
Male
,
Maze Learning - physiology
,
Memory - physiology
,
Memory Disorders - etiology
,
Memory Disorders - physiopathology
,
Mice
,
Mice, 129 Strain
,
Mice, Inbred C57BL
,
Morris water maze
,
Nerve Net - physiology
,
Nerve Tissue Proteins - biosynthesis
,
Nerve Tissue Proteins - genetics
,
Neurogenesis
,
Neuronal Plasticity - physiology
,
Neurons - physiology
,
Pentylenetetrazole - toxicity
,
Proto-Oncogene Proteins c-fos - biosynthesis
,
Seizures - chemically induced
,
Seizures - physiopathology
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