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Recent advances in the phylogenetic study of ghrelin
Ist Teil von
Peptides (New York, N.Y. : 1980), 2011-11, Vol.32 (11), p.2155-2174
Ort / Verlag
New York, NY: Elsevier Inc
Erscheinungsjahr
2011
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
► Ghrelin is a multifunctional hormone with more features than we have originally postulated. ► To understand what is ghrelin, it is also important to know the evolutional process. ► Ghrelin is present in non-mammalian vertebrates and plays crucial roles. ► Comparative study between mammalian and non-mammalian vertebrates let us know the generality and difference. ► In this review, we summarized recent literatures on the ghrelin system of non-mammalian vertebrates.
To understand fully the biology of ghrelin, it is important to know the evolutionary history of ghrelin and its receptor. Phylogenetic and comparative genomic studies of mammalian and non-mammalian vertebrates are a useful approach to that end. Ghrelin is a hormone that has apparently evaded natural selection during a long evolutionary history. Surely ghrelin plays crucial physiological roles in living animals. Phylogenetic studies reveal the nature and evolutionary history of this important signaling system.