Details

Autor(en) / Beteiligte

• Tasset, Inmaculada
• Agüera, Eduardo
• Olmo-Camacho, Rosa
• Escribano, Begoña
• Sánchez-López, Fernando
• Delgado, María J.
• Cruz, Antonio H.
• Gascón, Felix
• Luque, Evelio
• Peña, José
• Jimena, Ignacio M.
• Túnez, Isaac

Titel

Melatonin improves 3-nitropropionic acid induced behavioral alterations and neurotrophic factors levels

Ist Teil von

• Progress in neuro-psychopharmacology & biological psychiatry, 2011-12, Vol.35 (8), p.1944-1949

Ort / Verlag

Amsterdam: Elsevier Inc

Erscheinungsjahr

2011

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• This study sought to determine whether melatonin causes changes in neurotrophic factors and it protects against the mycotoxin 3-nitropropionic acid (3-NP) in brain tissue. Rats were given 3-NP over four consecutive days (20mg/kg BW), while melatonin was administered over 21days (1mg/kg/BW), starting after the last injection of 3-NP. Rats treated with 3-NP displayed significant changes in neurotrophic factor (BDNF and GDNF) levels, together with alterations in behavior; they also displayed extensive oxidative stress and a massive neuronal damage. Melatonin improved behavioral alterations, reduced oxidative damage, lowered neurotrophic factor levels and neuronal loss in 3-NP-treated rats. These results suggest that melatonin exerts a neuroprotective action. ► Melatonin has an antidepressive and anxiolytic effect. ► Melatonin reverses the oxidative and cellular damages caused by 3-NP. ► Melatonin reduces the levels of neurotrophic factors in animals treated with 3-NP.