Details

Autor(en) / Beteiligte

• Zhang, Hong-Wang
• Zhou, Longhu
• Coats, Steven J
• McBrayer, Tamara R
• Tharnish, Phillip M
• Bondada, Lavanya
• Detorio, Mervi
• Amichai, Sarah A
• Johns, Melissa D
• Whitaker, Tony
• Schinazi, Raymond F

Titel

Synthesis of purine modified 2&; prime; -C-methyl nucleosides as potential anti-HCV agents

Ist Teil von

• Bioorganic & medicinal chemistry letters, 2011-11, Vol.21 (22), p.6788-6792

Erscheinungsjahr

2011

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Based on the anti-hepatitis C activity of 2\'-C-methyl-adenosine and 2\'-C-methyl-guanosine, a series of new modified purine 2\'-C-methyl nucleosides was prepared as potential anti-hepatitis C virus agents. Herein, we report the synthesis of both 6-modified and 2-modified purine 2\'-C-methyl-nucleosides along with their anti-HCV replication activity and cytotoxicity in different cells.