Leukemia research, 2011-11, Vol.35 (11), p.1457-1463
2011
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Details
- Autor(en) / Beteiligte
- Titel
- Multidrug resistance gene expression and ABCB1 SNPs in plasma cell myeloma
- Ist Teil von
- Leukemia research, 2011-11, Vol.35 (11), p.1457-1463
- Ort / Verlag
- England: Elsevier Ltd
- Erscheinungsjahr
- 2011
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Highlights ► We investigated the expression of five prominent MDR genes in plasma cell myeloma. ► We suggest that ABCB4 is the most highly expressed in plasma cell myeloma. ► We also investigated the impact of ABCB1 SNPs on overall survival in plasma cell myeloma. ► We confirm that rs1045642 may mediate of overall survival in plasma cell myeloma. ► This effect is due solely to rs1045642 and not others within the common ABCB1 haplotype.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0145-2126eISSN: 1873-5835DOI: 10.1016/j.leukres.2011.05.033Titel-ID: cdi_proquest_miscellaneous_904494141
- Format
- –
- Schlagworte
- ABC transporters, Adult, Aged, ATP Binding Cassette Transporter, Sub-Family B - genetics, ATP Binding Cassette Transporter, Sub-Family G, Member 2, ATP-Binding Cassette Transporters - genetics, ATP-Binding Cassette, Sub-Family B, Member 1 - genetics, DNA, Neoplasm - genetics, Drug Resistance, Multiple - genetics, Drug Resistance, Neoplasm - genetics, Female, Gene expression, Haplotype, Hematology, Oncology and Palliative Medicine, Humans, Linkage Disequilibrium, Low Density Lipoprotein Receptor-Related Protein-1 - genetics, Male, Middle Aged, Multidrug resistance, Multidrug Resistance-Associated Proteins - genetics, Multiple Myeloma - genetics, Neoplasm Proteins - genetics, Neoplasm Recurrence, Local - genetics, Overall survival, Plasma cell myeloma, Polymorphism, Single Nucleotide - genetics, Prognosis, Real-Time Polymerase Chain Reaction, Reverse Transcriptase Polymerase Chain Reaction, RNA, Messenger - genetics, RNA, Neoplasm - genetics