Details

Autor(en) / Beteiligte

• Zhang, Ye
• Zou, Biqun
• Chen, Zhenfeng
• Pan, Yingming
• Wang, Hengshan
• Liang, Hong
• Yi, Xianghui

Titel

Synthesis and antioxidant activities of novel 4-Schiff base-7-benzyloxy-coumarin derivatives

Ist Teil von

• Bioorganic & medicinal chemistry letters, 2011-11, Vol.21 (22), p.6811-6815

Ort / Verlag

Amsterdam: Elsevier Ltd

Erscheinungsjahr

2011

Quelle

MEDLINE

Beschreibungen/Notizen

• 4-Schiff base-7-benzyloxy-coumarins 5a 1 – 5h 2 and its derivative 6 were designed and synthesized based on the 7-benzyloxy-coumarin structure as novel antioxidants. The in vitro antioxidant activities screening revealed that 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activities of compounds 5b 1 , 5d 1 , 5f 1 , 5f 2 , 5g 1 and 5g 2 , and 2,2′-azinobis-(3-ethylbenzthiazoline-6-sulfonate) cation (ABTS +) radical scavenging activities of compounds 5a 1 , 5b 1 , 5c 1 , 5c 2 , 5d 1 , 5e 1 , 5e 2 , 5f 2 , 5g 1 , 5g 2 and 5h 1 were better than that of the commercial antioxidant butylated hydroxytoluene (BHT), while the superoxide anion radical scavenging activities of 5a 2 and 5g 2 were stronger than that of the commercial antioxidant butylated hydroxyanisole (BHA), and the hydroxyl radical scavenging activity of 5e 1 was much better than that of the common antioxidant ascorbic acid.