Details

Autor(en) / Beteiligte

• Belyea, Brian
• Hinson, Ashley
• Moran, Cassandra
• Hwang, Eugene
• Heath, Jessica
• Barfield, Raymond

Titel

Spontaneous resolution of Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis

Ist Teil von

• Pediatric blood & cancer, 2010-10, Vol.55 (4), p.754-756

Ort / Verlag

Hoboken: Wiley Subscription Services, Inc., A Wiley Company

Erscheinungsjahr

2010

Quelle

Wiley-Blackwell Journals

Beschreibungen/Notizen

• Secondary hemophagocytic lymphohistiocytosis (sHLH) is a reactive, proliferative disorder of the immune system resulting in lymphohistiocytic proliferation, hemophagocytosis, and cytokine dysregulation. The most common infectious trigger in sHLH is Epstein–Barr virus (EBV‐HLH). Current treatment protocols for EBV‐HLH have a cure rate of approximately 75%; however, there are significant toxicities associated with these therapies. We present two patients with EBV‐HLH who experienced spontaneous resolution of their disease prior to the initiation of therapy, suggesting there may be a subgroup of patients with EBV‐HLH who do well with conservative management and can avoid potentially toxic therapies. Pediatr Blood Cancer. 2010;55:754–756. © 2010 Wiley‐Liss, Inc.