Details

Autor(en) / Beteiligte

• Ershova, SA
• Najakshin, A M
• Mechetina, LV
• Peklo, M M
• Shevelev, AYa
• Vlasik, T N
• Chikaev, NA
• Taranin, A V

Titel

Expression Patterns of the Human and Mouse IFGP Family Genes

Ist Teil von

• Molecular biology (New York), 2005-09, Vol.39 (5), p.675-683

Ort / Verlag

New York: Springer Nature B.V

Erscheinungsjahr

2005

Link zum Volltext

Quelle

SpringerLink (Online service)

Beschreibungen/Notizen

• The IFGP gene family has recently been found in human and mouse cells and is structurally related to the leukocytic Fc receptor genes. Expression of six human and four mouse IFGP genes was studied. Apart from mouse IFGP2, the genes of the family are expressed predominantly in hematopoietic cells. Expression of human IFGP1-IFGP5 and mouse IFGP3 is restricted to B cells. Mouse IFGP1 is expressed in B cells and, possibly, in nonlymphoid cells. IFGP6 is specifically expressed in CD8+ T cells and natural killers. Alternative splicing was demonstrated for the first time for the human IFGP1 and IFGP6 mRNAs. The alternative transcripts code for an IGFP1 isoform devoid of the transmembrane domain and an IFGP6 isoform with a changed cytoplasmic tail. It was assumed that the receptors of the family play a role in controlling differentiation and/or function of effector lymphocytes of the three main types: B cells, CD8+ T cells, and natural killers.