Details

Autor(en) / Beteiligte

• Dieter, Sebastian M.
• Ball, Claudia R.
• Hoffmann, Christopher M.
• Nowrouzi, Ali
• Herbst, Friederike
• Zavidij, Oksana
• Abel, Ulrich
• Arens, Anne
• Weichert, Wilko
• Brand, Karsten
• Koch, Moritz
• Weitz, Jürgen
• Schmidt, Manfred
• von Kalle, Christof
• Glimm, Hanno

Titel

Distinct Types of Tumor-Initiating Cells Form Human Colon Cancer Tumors and Metastases

Ist Teil von

• Cell stem cell, 2011-10, Vol.9 (4), p.357-365

Ort / Verlag

Cambridge, MA: Elsevier Inc

Erscheinungsjahr

2011

Quelle

The Electronic Journals Library

Beschreibungen/Notizen

• Human colon cancer harbors a small subfraction of tumor-initiating cells (TICs) that is assumed to be a functionally homogeneous stem-cell-like population driving tumor maintenance and metastasis formation. We found unexpected cellular heterogeneity within the TIC compartment, which contains three types of TICs. Extensively self-renewing long-term TICs (LT-TICs) maintained tumor formation in serial xenotransplants. Tumor transient amplifying cells (T-TACs) with limited or no self-renewal capacity contributed to tumor formation only in primary mice. Rare delayed contributing TICs (DC-TICs) were exclusively active in secondary or tertiary mice. Bone marrow was identified as an important reservoir of LT-TICs. Metastasis formation was almost exclusively driven by self-renewing LT-TICs. Our results demonstrate that tumor initiation, self-renewal, and metastasis formation are limited to particular subpopulations of TICs in primary human colon cancer. We identify LT-TICs as a quantifiable target for therapies aimed toward eradication of self-renewing tumorigenic and metastatic colon cancer cells. [Display omitted] ► Human colon cancer contains distinct classes of tumor-initiating cells ► Self-renewal is limited to long-term TICs but not tumor transient amplifying cells ► Metastasis formation is exclusively driven by long-term TICs ► TICs home to and persist in the bone marrow