Details

Autor(en) / Beteiligte

• Pérez-Rojas, Jazmin M.
• Guerrero-Beltrán, Carlos Enrique
• Cruz, Cristino
• Sánchez-González, Dolores J.
• Martínez-Martínez, Claudia M.
• Pedraza-Chaverri, José

Titel

Preventive effect of tert-butylhydroquinone on cisplatin-induced nephrotoxicity in rats

Ist Teil von

• Food and chemical toxicology, 2011-10, Vol.49 (10), p.2631-2637

Ort / Verlag

Oxford: Elsevier Ltd

Erscheinungsjahr

2011

Quelle

MEDLINE

Beschreibungen/Notizen

• [Display omitted] ► tBHQ prevents the acute renal failure induced by cisplatin. ► Renoprotection was associated to the antioxidant effect of tBHQ. ► tBHQ may be useful during cancer cisplatin chemotherapy. Cis-diamminedichloroplatinum II (CDDP)-induced nephrotoxicity is associated with the overproduction of reactive oxygen species. tert-Butylhydroquinone (tBHQ) is a compound widely used as food antioxidant. The purpose of this study was to investigate the ability of tBHQ to prevent the nephrotoxic effect of CDDP in rats as well as the mechanisms involved. Thirty-six Wistar rats divided in the following groups were used: control, tBHQ (12.5mg/kg), CDDP (7.5mg/kg) and tBHQ+CDDP. Twenty-four h urine was collected at the beginning and at the end of the experiment and the rats were sacrificed 72h after CDDP-administration. Histological studies were performed and markers of renal function and oxidative/nitrosative stress were measured. In addition, the activity of the following antioxidant enzymes was measured: glutathione peroxidase (GPx), superoxide dismutase (SOD), glutathione reductase (GR) and glutathione-S-transferase (GST). CDDP-induced renal dysfunction, structural damage and oxidative/nitrosative were prevented by tBHQ. In addition, tBHQ completely prevented the CDDP-induced fall in GPx and GST activities. In conclusion, the present study indicates that the antioxidant activity of tBHQ is associated with its nephroprotective effect against CDDP-induced acute kidney injury in rats.