UNIVERSI
TÄ
TS-
BIBLIOTHEK
P
ADERBORN
Anmelden
Menü
Menü
Start
Hilfe
Blog
Weitere Dienste
Neuerwerbungslisten
Fachsystematik Bücher
Erwerbungsvorschlag
Bestellung aus dem Magazin
Fernleihe
Einstellungen
Sprache
Deutsch
Deutsch
Englisch
Farbschema
Hell
Dunkel
Automatisch
Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist
gegebenenfalls
nur via VPN oder Shibboleth (DFN-AAI) möglich.
mehr Informationen...
Universitätsbibliothek
Katalog
Suche
Details
Zur Ergebnisliste
Ergebnis 5 von 134
Datensatz exportieren als...
BibTeX
The effect of adding PTH(1–84) to conventional treatment of hypoparathyroidism: A randomized, placebo‐controlled study
Journal of bone and mineral research, 2011-10, Vol.26 (10), p.2358-2370
Sikjaer, Tanja
Rejnmark, Lars
Rolighed, Lars
Heickendorff, Lene
Mosekilde, Leif
2011
Details
Autor(en) / Beteiligte
Sikjaer, Tanja
Rejnmark, Lars
Rolighed, Lars
Heickendorff, Lene
Mosekilde, Leif
Titel
The effect of adding PTH(1–84) to conventional treatment of hypoparathyroidism: A randomized, placebo‐controlled study
Ist Teil von
Journal of bone and mineral research, 2011-10, Vol.26 (10), p.2358-2370
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2011
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
In hypoparathyroidism, plasma parathyroid hormone (PTH) levels are inadequate to maintain plasma calcium concentration within the reference range. On conventional treatment with calcium supplements and active vitamin D analogues, bone turnover is abnormally low, and BMD is markedly increased. We aimed to study the effects of PTH‐replacement therapy (PTH‐RT) on calcium‐phosphate homeostasis and BMD. In a double‐blind design, we randomized 62 patients with hypoparathyroidism to daily treatment with PTH(1–84) 100 µg or similar placebo for 24 weeks as add‐on therapy to conventional treatment. Compared with placebo, patients on PTH(1–84) reduced their daily dose of calcium and active vitamin D significantly by 75% and 73%, respectively, without developing hypocalcemia. However, hypercalcemia occurred frequently during the downtitration of calcium and active vitamin D. Plasma phosphate and renal calcium and phosphate excretion did not change. Compared with placebo, PTH(1–84) treatment significantly increased plasma levels of bone‐specific alkaline phosphatase (+226% ± 36%), osteocalcin (+807% ± 186%), N‐terminal propeptide of procollagen 1 (P1NP; +1315% ± 330%), cross‐linked C‐telopeptide of type 1 collagen (CTX; +1209% ± 459%), and urinary cross‐linked N‐telopeptide of type 1 collagen (NTX; (+830% ± 165%), whereas BMD decreased at the hip (−1.59% ± 0.57%), lumbar spine (−1.76% ± 1.03%), and whole body (−1.26% ± 0.49%) but not at the forearm. In conclusion, the need for calcium and active vitamin D is reduced significantly during PTH‐RT, whereas plasma calcium and phosphate levels are maintained within the physiologic range. In contrast to the effect of PTH(1–84) treatment in patients with osteoporosis, PTH‐RT in hypoparathyroidism causes a decrease in BMD. This is most likely due to the marked increased bone turnover. Accordingly, PTH‐RT counteracts the state of overmineralized bone and, during long‐term treatment, may cause a more physiologic bone metabolism. © 2011 American Society for Bone and Mineral Research
Sprache
Englisch
Identifikatoren
ISSN: 0884-0431
eISSN: 1523-4681
DOI: 10.1002/jbmr.470
Titel-ID: cdi_proquest_miscellaneous_902364200
Format
–
Schlagworte
Adult
,
Aged
,
Ascorbic Acid - administration & dosage
,
Biological and medical sciences
,
BONE DENSIOMETRY
,
Bone Density
,
Calcium - administration & dosage
,
Calcium - metabolism
,
CLINICAL TRIALS
,
Female
,
Fundamental and applied biological sciences. Psychology
,
Homeostasis
,
Humans
,
HYPOPARATHYROIDISM
,
Hypoparathyroidism - drug therapy
,
Hypoparathyroidism - physiopathology
,
Male
,
Middle Aged
,
PARATHYROID
,
Parathyroid Hormone - adverse effects
,
Parathyroid Hormone - therapeutic use
,
Phosphorus - metabolism
,
Placebos
,
PTH/PTH‐RT
,
Skeleton and joints
,
Vertebrates: osteoarticular system, musculoskeletal system
Weiterführende Literatur
Empfehlungen zum selben Thema automatisch vorgeschlagen von
bX