Details

Autor(en) / Beteiligte

• Michel, Grégory
• Pomares, Christelle
• Ferrua, Bernard
• Marty, Pierre

Titel

Importance of worldwide asymptomatic carriers of Leishmania infantum (L. chagasi) in human

Ist Teil von

• Acta tropica, 2011-08, Vol.119 (2-3), p.69-75

Ort / Verlag

Oxford: Elsevier B.V

Erscheinungsjahr

2011

Quelle

MEDLINE

Beschreibungen/Notizen

• Human clinical cases of visceral leishmaniasis represent only the tip of the iceberg, most infections lead to an asymptomatic form. Consequences of the presence of asymptomatic carriers of Leishmania infantum were reviewed. Leishmaniasis due to Leishmania infantum (syn. L. chagasi) infection is a zoonotic disease present mainly in Mediterranean basin, central Asia and Brazil. Besides a limited number of human cases of clinical visceral leishmaniasis, a great number of infections remains asymptomatic. In this review, the prevalence of asymptomatic carriers of L. infantum was evaluated worldwide using parasitological methods or indirect testing such as a skin test or serology. The consequences of the presence of asymptomatic carriers on parasite transmission by blood donation or the development of clinical visceral leishmaniasis in immunocompromised individuals and its possible role as reservoir are discussed.