Details

Autor(en) / Beteiligte

• Hou, Wei
• Xia, Bing
• Yuan, Anlong
• Li, Jin
• Yang, Zhanqiu
• Mao, Lin

Titel

CTLA‐4 gene polymorphisms in Chinese patients with ulcerative colitis

Ist Teil von

• Inflammatory bowel diseases, 2005-07, Vol.11 (7), p.653-656

Ort / Verlag

Philadelphia: Lippincott Williams & Wilkins, Inc

Erscheinungsjahr

2005

Link zum Volltext

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Background: Ulcerative colitis (UC) is characterized by chronic inflammation of the colon and rectum as a result of an exaggerated T‐cell response. Cytotoxic T lymphocyte‐associated antigen 4 (CTLA‐4) is a T cell‐restricted surface molecule induced with TCR or CD28 activation. There is evidence for genetic involvement of CTLA‐4 in several autoimmune diseases, with the focus on the possible role of genetic variation of the CTLA‐4 locus. The aim of this study was to investigate CTLA‐4 gene polymorphisms in patients with UC in a Chinese population with Han nationality. Methods: The C−318T polymorphism in the promoter region and A+49G polymorphism in exon 1 of the CTLA‐4 gene were studied by a polymerase chain reaction‐sequence‐specific primer method. We studied 82 unrelated patients with UC and 204 healthy controls in a Chinese population with Han nationality. Results: The frequency of the haplotype 2,3 (−318C+49G/−318T+49A) was 26% in patients with UC and 41% in healthy controls (Fisher exact test P = 0.0147, odds ratio = 0.4918, 95% confidence interval: 0.2784 ∼ 0.8688), but this significance disappeared when Bonferoni correction was applied. No other significant differences in the distribution of allele and genotype frequencies were observed between C−318T and A+49G gene polymorphisms and UC in the Chinese Han population. Conclusion: The C−318T and A+49G polymorphisms of the CTLA‐4 gene were not associated with UC in Chinese Han patients.