Details

Autor(en) / Beteiligte

• Teng, Ying-Hock
• Liu, Te-Hsiung
• Tseng, Hsien-Chun
• Chung, Tsung-Te
• Yeh, Chia-Ming
• Li, Yu-Chiung
• Ou, Yu-Hsiang
• Lin, Long-Yau
• Tsai, Hsiu-Ting
• Yang, Shun-Fa

Titel

Contribution of genetic polymorphisms of stromal cell-derived factor-1 and its receptor, CXCR4, to the susceptibility and clinicopathologic development of oral cancer

Ist Teil von

• Head & neck, 2009-10, Vol.31 (10), p.1282-1288

Ort / Verlag

Hoboken: Wiley Subscription Services, Inc., A Wiley Company

Erscheinungsjahr

2009

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Background. The aim of this study was to evaluate the relations of SDF‐1 and its receptor, CXCR4, gene variants on oral cancer risk. Methods. PCR‐RFLP was used to measure SDF‐1‐3′A and CXCR4 gene polymorphisms in 284 controls and 113 patients with oral cancer. Results. After being adjusted for age, individuals with A/G heterozygotes of SDF‐1 had a higher risk of 1.86‐fold to develop oral cancer when compared with those with G/G wild type homozygotes. Furthermore, patients with oral cancer with at least 1 mutant T allele of CXCR4 gene had a risk of 2.66‐fold to progress to stage III or IV. Conclusions. SDF‐1‐3′A gene polymorphism may be considered as a factor of increased susceptibility to oral cancer, and at least 1 mutated T allele of CXCR4 gene is associated with the development of stage III or IV and the induction of lymph‐node metastasis of oral cancer disease in Taiwanese. © 2009 Wiley Periodicals, Inc. Head Neck, 2009