Details

Autor(en) / Beteiligte

• Zhang, Bo-yu
• He, Wei-Dong
• Li, Li-ying
• Sun, Xiao-li
• Li, Wen-tao
• Zhang, Ke-ren

Titel

Reducibly degradable hydrogels of PNIPAM and PDMAEMA: Synthesis, stimulus-response and drug release

Ist Teil von

• Journal of polymer science. Part A, Polymer chemistry, 2010-08, Vol.48 (16), p.3604-3612

Ort / Verlag

Hoboken: Wiley Subscription Services, Inc., A Wiley Company

Erscheinungsjahr

2010

Quelle

Wiley-Blackwell Journals

Beschreibungen/Notizen

• Reducibly degradable hydrogels of poly(N-isopropylacrylamide) (PNIPAM) and poly(N,N-dimethylaminoethyl methacrylate) (PDMAEMA) were synthesized by the combination of reversible addition-fragmentation chain transfer (RAFT) polymerization and click chemistry. The alkyne-pending copolymer of PNIPAM or PDMAEMA was obtained through RAFT copolymerization of propargyl acrylate with NIPAM or DMAEMA. Bis-2-azidyl-isobutyrylamide of cystamine (AIBCy) was used as the crosslinking reagent to prepare reducibly degradable hydrogels by click chemistry. The hydrogels exhibited temperature or pH stimulus-responsive behavior in water, with rapid response, high swelling ratio, and reproducible swelling/shrinkage cycles. The loading and release of ceftriaxone sodium proved the feasibility of the hydrogels as the stimulus-responsive drug delivery system. Furthermore, the presence of disulfide linkage in AIBCy favored the degradation of hydrogels in the reductive environment.