Details

Autor(en) / Beteiligte

• Palefsky, Joel M
• Giuliano, Anna R
• Goldstone, Stephen
• Moreira, Edson D
• Aranda, Carlos
• Jessen, Heiko
• Hillman, Richard
• Ferris, Daron
• Coutlee, Francois
• Stoler, Mark H
• Marshall, J. Brooke
• Radley, David
• Vuocolo, Scott
• Haupt, Richard M
• Guris, Dalya
• Garner, Elizabeth I.O

Titel

HPV Vaccine against Anal HPV Infection and Anal Intraepithelial Neoplasia

Ist Teil von

• The New England journal of medicine, 2011-10, Vol.365 (17), p.1576-1585

Ort / Verlag

Waltham, MA: Massachusetts Medical Society

Erscheinungsjahr

2011

Quelle

MEDLINE

Beschreibungen/Notizen

• Infection with human papillomavirus (HPV) serotypes 16 and 18 in men who have sex with men is a cause of considerable morbidity associated with anal intraepithelial neoplasia. This study shows that the HPV vaccine decreases the risk of HPV-associated anal disease. Anal cancer is biologically similar to cervical cancer, including having a causal relationship with human papillomavirus (HPV) infection. 1 Although HPV type 6 (HPV-6) or HPV type 11 (HPV-11) alone is rarely causal, the proportion of anal cancers associated with infection with HPV type 16 (HPV-16) or HPV type 18 (HPV-18) is as high as or higher than the proportion of cervical cancers. 1 Just as cervical cancer is preceded by high-grade cervical intraepithelial neoplasia (grade ≥2), anal cancer is preceded by high-grade anal intraepithelial neoplasia (grade 2 or 3). 2 – 4 Although not yet formally demonstrated, prevention or treatment of high-grade anal . . .