Details

Autor(en) / Beteiligte

• Hutchinson, J
• Lentjes, M
• Greenwood, D
• Burley, V
• Cade, J
• Cleghorn, C
• Threapleton, D
• Key, T
• Cairns, B
• Keogh, R
• Dahm, C
• Brunner, E
• Shipley, M
• Kuh, D
• Mishra, G
• Stephen, A
• Bhaniani, A
• Borgulya, G
• Khaw, K T
• Rodwell, S

Titel

P2-118 Vitamin C intake from diary recordings and risk of breast cancer in the UK dietary cohort consortium

Ist Teil von

• Journal of epidemiology and community health (1979), 2011-08, Vol.65 (Suppl 1), p.A253-A253

Ort / Verlag

London: BMJ Publishing Group Ltd

Erscheinungsjahr

2011

Quelle

BMJ Journals Archiv - DFG Nationallizenzen

Beschreibungen/Notizen

• IntroductionVitamin C intake has been inversely associated with breast cancer risk in case-control studies, but not in meta-analyses of cohort studies using Food Frequency Questionnaires. No study has assessed this relationship prospectively using food diaries which may more accurately measure intake.MethodsEstimated dietary vitamin C intake was derived from 4 to 7 day food diaries pooled from five prospective studies in the UK Dietary Cohort Consortium. This nested case-control study of 851 incident breast cancer cases and 2727 matched controls examined breast cancer risk in relation to dietary vitamin C intake using conditional logistic regression adjusting for relevant covariates. Additionally, total vitamin C intake from supplements and diet was analysed in the three largest cohorts.ResultsNo evidence of an association was observed between breast cancer risk and dietary (OR=1.00 per 60 mg/d, 95% CI 0.91 to 1.09, Ptrend=1.0) or total vitamin C intake (OR=1.01 per 60 mg/d, 95% CI 1.00 to 1.03, Ptrend=0.1) in analyses using continuous estimates or by fifths of intake. Additionally, there was no association for post-menopausal women.ConclusionsThis pooled analysis of individual UK women found no evidence of associations between breast cancer incidence and dietary or total vitamin C intake derived uniquely from detailed diary recordings.