Toxicology (Amsterdam), 2011-09, Vol.287 (1), p.124-130
2011
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Details
- Autor(en) / Beteiligte
- Titel
- Ginkgolide B attenuates ethanol-induced neurotoxicity through regulating NADPH oxidases
- Ist Teil von
- Toxicology (Amsterdam), 2011-09, Vol.287 (1), p.124-130
- Ort / Verlag
- Kidlington: Elsevier Ireland Ltd
- Erscheinungsjahr
- 2011
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Highlights ► GB inhibited ethanol-induced cell injury, apoptosis, and activities of caspase-3. ► GB decreased the production of ROS and lipid peroxides induced by ethanol. ► Ethanol increased mRNA and protein expression of NADPH oxidases. ► Expression and activities of NADPH oxidases were down-regulated by GB.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0300-483XeISSN: 1879-3185DOI: 10.1016/j.tox.2011.06.006Titel-ID: cdi_proquest_miscellaneous_899143562
- Format
- –
- Schlagworte
- alcohol dehydrogenase, Alcoholism and acute alcohol poisoning, Animals, Apoptosis, Apoptosis - drug effects, Biological and medical sciences, caspase-3, central nervous system, cytotoxicity, Emergency, endothelial cells, enzyme activity, Ethanol, Ethanol - toxicity, Ginkgolides - pharmacology, L-Lactate Dehydrogenase - secretion, Lactones - pharmacology, Lipid Peroxidation - drug effects, Medical sciences, messenger RNA, myocytes, NADPH oxidases, NADPH Oxidases - metabolism, neurons, neurotoxicity, Neurotoxicity Syndromes - drug therapy, Neurotoxicity Syndromes - metabolism, Oriental traditional medicine, oxidative stress, PC12 Cells, peroxides, protein synthesis, quantitative polymerase chain reaction, Rats, Reactive oxygen species, Reactive Oxygen Species - metabolism, smooth muscle, Toxicology, Western blotting