Nature genetics, 2011-09, Vol.43 (9), p.897-901
- XUN CHU
- PAN, Chun-Ming
- WEI LIU
- FANG XIE
- YANG, Shao-Ying
- WANG, Hai-Feng
- SHI, Jing-Yi
- SUN, Wei-Wei
- DU, Wen-Hua
- ZUO, Chun-Lin
- SHI, Jin-Xiu
- LIU, Bing-Li
- ZHAO, Shuang-Xia
- GUO, Cui-Cui
- MING ZHAN
- GU, Zhao-Hui
- ZHANG, Xiao-Na
- FEI SUN
- WANG, Zhi-Quan
- SONG, Zhi-Yi
- ZOU, Cai-Yan
- SUN, Wei-Hua
- TING GUO
- JUN LIANG
- CAO, Huang-Ming
- MA, Jun-Hua
- BING HAN
- PING LI
- HE JIANG
- HUANG, Qiu-Hua
- LIMING LIANG
- LIU, Li-Bin
- GANG CHEN
- QING SU
- GAO, Guan-Qi
- PENG, Yong-De
- ZHAO, Jia-Jun
- GUANG NING
- ZHU CHEN
- CHEN, Jia-Lun
- CHEN, Sai-Juan
- WEI HUANG
- SONG, Huai-Dong
- ZHANG, Xiao-Mei
- YUAN, Guo-Yue
- LI, Chang-Gui
- XUE, Li-Qiong
- MIN SHEN
2011
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- Autor(en) / Beteiligte
- XUN CHU
- PAN, Chun-Ming
- WEI LIU
- FANG XIE
- YANG, Shao-Ying
- WANG, Hai-Feng
- SHI, Jing-Yi
- SUN, Wei-Wei
- DU, Wen-Hua
- ZUO, Chun-Lin
- SHI, Jin-Xiu
- LIU, Bing-Li
- ZHAO, Shuang-Xia
- GUO, Cui-Cui
- MING ZHAN
- GU, Zhao-Hui
- ZHANG, Xiao-Na
- FEI SUN
- WANG, Zhi-Quan
- SONG, Zhi-Yi
- ZOU, Cai-Yan
- SUN, Wei-Hua
- TING GUO
- JUN LIANG
- CAO, Huang-Ming
- MA, Jun-Hua
- BING HAN
- PING LI
- HE JIANG
- HUANG, Qiu-Hua
- LIMING LIANG
- LIU, Li-Bin
- GANG CHEN
- QING SU
- GAO, Guan-Qi
- PENG, Yong-De
- ZHAO, Jia-Jun
- GUANG NING
- ZHU CHEN
- CHEN, Jia-Lun
- CHEN, Sai-Juan
- WEI HUANG
- SONG, Huai-Dong
- ZHANG, Xiao-Mei
- YUAN, Guo-Yue
- LI, Chang-Gui
- XUE, Li-Qiong
- MIN SHEN
- Titel
- A genome-wide association study identifies two new risk loci for Graves' disease
- Ist Teil von
- Nature genetics, 2011-09, Vol.43 (9), p.897-901
- Ort / Verlag
- New York: Nature Publishing Group US
- Erscheinungsjahr
- 2011
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Graves' disease is a common autoimmune disorder characterized by thyroid stimulating hormone receptor autoantibodies (TRAb) and hyperthyroidism. To investigate the genetic architecture of Graves' disease, we conducted a genome-wide association study in 1,536 individuals with Graves' disease (cases) and 1,516 controls. We further evaluated a group of associated SNPs in a second set of 3,994 cases and 3,510 controls. We confirmed four previously reported loci (in the major histocompatibility complex, TSHR, CTLA4 and FCRL3) and identified two new susceptibility loci (the RNASET2-FGFR1OP-CCR6 region at 6q27 (Pcombined = 6.85 × 10−10 for rs9355610) and an intergenic region at 4p14 (Pcombined = 1.08 × 10−13 for rs6832151)). These newly associated SNPs were correlated with the expression levels of RNASET2 at 6q27, of CHRNA9 and of a previously uncharacterized gene at 4p14, respectively. Moreover, we identified strong associations of TSHR and major histocompatibility complex class II variants with persistently TRAb-positive Graves' disease.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1061-4036eISSN: 1546-1718DOI: 10.1038/ng.898Titel-ID: cdi_proquest_miscellaneous_896834276
- Format
- –
- Schlagworte
- 631/208/205/2138, 631/208/727/2000, 692/308/2779/174, 692/699/249/1313, Agriculture, Animal Genetics and Genomics, Autoantibodies - blood, Biological and medical sciences, Biomedical and Life Sciences, Biomedicine, Cancer Research, Classical genetics, quantitative genetics, hybrids, Disease, Endocrinopathies, Female, Fundamental and applied biological sciences. Psychology, Gene expression, Gene Function, Genetic aspects, Genetic Loci, Genetic Predisposition to Disease, Genetics of eukaryotes. Biological and molecular evolution, Genome-Wide Association Study, Genomes, Graves Disease - epidemiology, Graves Disease - genetics, Graves Disease - immunology, Graves' disease, Histocompatibility Antigens Class II - genetics, Human, Human Genetics, Humans, letter, Male, Medical sciences, Molecular Sequence Data, Non tumoral diseases. Target tissue resistance. Benign neoplasms, Physiological aspects, Polymerase chain reaction, Principal components analysis, Quality control, Receptors, Thyrotropin - genetics, Receptors, Thyrotropin - immunology, Regression analysis, Risk, Risk factors, Thyroid, Thyroid. Thyroid axis (diseases)