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Summary
Objective To determine the frequency distribution of LMNA 1908C>T SNP and its association with generalized obesity, abdominal obesity and coexistent metabolic disorders in nondiabetic Asian Indians living in a metropolitan city of north India.
Design A cross‐sectional population‐based study of LMNA 1908C>T polymorphism with obesity and insulin resistance as outcome.
Patients Five hundred and fifty‐one Asian Indians, with 240 obese and 289 nonobese subjects.
Measurements Allelic and genotypic frequency of LMNA 1908C>T were determined by PCR‐RFLP. Association of LMNA alleles and genotypes was analysed with various measures of obesity [BMI ≥25 kg/m2, percentage body fat (by DEXA); subcutaneous and intra‐abdominal fat at L2–3 level by single slice MRI in a subsample and surrogate marker of insulin resistance (fasting serum insulin levels >10 μU/ml in men and >11 μU/ml in women).
Results Forty‐six per cent of the subjects had generalized obesity while 54% had abdominal obesity. Frequency of C and T alleles was 0·71 and 0·29, respectively. Higher frequency of variant allele (T) was observed in obese than nonobese individuals (P = 0·001). On multivariate analysis adjusting for age, gender and serum insulin levels, subjects with LMNA1908T/T genotype were at 5·6 times higher risk [OR (95% CI): 5·6 (2·5–12·2), P = 0·001], while individuals with genotypes with at least one T allele, i.e. 1908C/T and T/T genotypes, were at 2·7 times higher odds to develop generalized obesity [OR (95% CI): 2·7 (1·8–4·1), P = 0·001].
Conclusion LMNA 1908T/T and C/T genotypes emerged as independent genetic risk factors for generalized obesity in Asian north Indians.