Details

Autor(en) / Beteiligte

• Lee, Yoo-Young
• Kim, Tae-Joong
• Kim, Min-Ji
• Kim, Ha-Jeong
• Song, Taejong
• Kim, Min Kyu
• Choi, Chel Hun
• Lee, Jeong-Won
• Bae, Duk-Soo
• Kim, Byoung-Gie

Titel

Prognosis of ovarian clear cell carcinoma compared to other histological subtypes: A meta-analysis

Ist Teil von

• Gynecologic oncology, 2011-09, Vol.122 (3), p.541-547

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2011

Quelle

MEDLINE

Beschreibungen/Notizen

• Abstract Objective To compare the survival outcome between clear cell carcinoma (CCC) and other histological subtypes in epithelial ovarian carcinoma (EOC). Methods From January 1974 to February 2011, we identified a total of 31,800 (CCC; 2152, non-CCC; 29648) patients from 12 studies meeting the inclusion criteria. Results Heterogeneity tests demonstrated significant between-study variation ( I2 = 92.1%) with no significant difference in hazard ratio (HR) for death between CCC and non-CCC (HR; 1.16, 95% CI; 0.85–1.57, random-effects model). Comparing the HR based on stage I + II, and stage III + IV, between CCC and non-CCC, showed that CCC patients had a higher hazard rate for death than those with non-CCC of the ovary (stage I + II; HR; 1.17, 95% CI; 1.01–1.36, stage III + IV; HR; 1.65, 95% CI; 1.52–1.79). In a comparison of CCC and serous EOC, advanced stage (III and IV) CCC only showed a poorer hazard rate for death than serous EOC (HR; 1.71, 95% CI; 1.57–1.86). Conclusion This analysis suggests that ovarian CCC patients had poorer prognosis than those with other histological subtypes of EOC, especially in advanced EOC stages. Different treatment strategies may be needed for patients with ovarian CCC.