Details

Autor(en) / Beteiligte

• Delmas, Thomas
• Couffin, Anne-Claude
• Bayle, Pierre Alain
• Crécy, François de
• Neumann, Emmanuelle
• Vinet, Françoise
• Bardet, Michel
• Bibette, Jérôme
• Texier, Isabelle

Titel

Preparation and characterization of highly stable lipid nanoparticles with amorphous core of tuneable viscosity

Ist Teil von

• Journal of colloid and interface science, 2011-08, Vol.360 (2), p.471-481

Ort / Verlag

Amsterdam: Elsevier Inc

Erscheinungsjahr

2011

Quelle

MEDLINE

Beschreibungen/Notizen

• Fluid or gel formulations of stable lipid nanoparticles with a non-crystalline core, whose viscosity can be finely tuned by the lipid composition and the temperature, are described. [Display omitted] ► Fluid or gel formulations of stable lipid nanoparticles are achieved. ► The nanoparticle core is non-crystalline. ► The core viscosity can be tuned by the lipid composition and the temperature. ► A design of experiments investigates the limits of the system colloidal stability. Lipid nanoparticles (LNP) have been designed based on low cost and human-use approved excipients, and manufactured by an easy, robust, and up-scalable process. Fluid colloidal dispersions or gel viscous formulations of highly stable nanoparticles (more than 12month stability is achieved for some formulations) can be obtained. Their physicochemical properties are studied by Dynamic Light Scattering, Differential Scanning Calorimetry, and NMR. The results picture nanoparticles with a non-crystalline core, which viscosity can be finely tuned by the lipid composition and the temperature. A design of experiments has been used to investigate the limits of the system colloidal stability. The impact of core and surfactant weight fractions have been explored both experimentally and using the design of experiments. The versatility of this physicochemical system could open the way to a wide range of future pharmaceutical applications.