International journal of cardiology, 2011-09, Vol.151 (3), p.307-312
2011
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- Autor(en) / Beteiligte
- Titel
- Replacement therapy for iron deficiency improves exercise capacity and quality of life in patients with cyanotic congenital heart disease and/or the Eisenmenger syndrome
- Ist Teil von
- International journal of cardiology, 2011-09, Vol.151 (3), p.307-312
- Ort / Verlag
- Shannon: Elsevier Ireland Ltd
- Erscheinungsjahr
- 2011
- Quelle
- ScienceDirect
- Beschreibungen/Notizen
- Abstract Introduction Iron deficiency is common in cyanotic congenital heart disease (CHD) and results in reduced exercise tolerance. Currently, iron replacement is advocated with limited evidence in cyanotic CHD. We investigated the safety and efficacy of iron replacement therapy in this population. Methods Twenty-five iron-deficient cyanotic CHD patients were prospectively studied between August 2008 and January 2009. Oral ferrous fumarate was titrated to a maximum dose of 200 mg thrice-daily. The CAMPHOR QoL questionnaire, 6 minute walk test (6MWT) and cardiopulmonary exercise testing were conducted at baseline and after 3 months of treatment. Results Mean age was 39.9 ± 10.9 years, 80% females. Fourteen had Eisenmenger syndrome, 6 complex cyanotic disease and 5 Fontan circulation. There were no adverse effects necessitating termination of treatment. After 3 months of treatment, hemoglobin (19.0 ± 2.9 g/dL to 20.4 ± 2.7 g/dL, p < 0.001), ferritin (13.3 ± 4.7 μg/L to 54.1 ± 24.2 μg/L, p < 0.001) and transferrin saturation (17.8 ± 9.6% to 34.8 ± 23.4%, p < 0.001) significantly increased. Significant improvements were also detected in the total CAMPHOR score (20.7 ± 10.9 to 16.2 ± 10.4, p = 0.001) and 6MWT distance (371.7 ± 84.7 m to 402.8.0 ± 74.9 m, p = 0.001). Peak VO2 remained unchanged (40.7 ± 9.2% to 43.8 ± 12.4% of predicted, p = 0.15). Conclusion Three months of iron replacement therapy in iron-deficient cyanotic CHD patients was safe and resulted in significant improvement in exercise tolerance and quality of life. Identification of iron deficiency and appropriate replacement should be advocated in these patients.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0167-5273eISSN: 1874-1754DOI: 10.1016/j.ijcard.2010.05.066Titel-ID: cdi_proquest_miscellaneous_889178510
- Format
- –
- Schlagworte
- Adult, Anemia, Iron-Deficiency - drug therapy, Anemia, Iron-Deficiency - physiopathology, Anemia, Iron-Deficiency - psychology, Anemias. Hemoglobinopathies, Biological and medical sciences, Cardiology. Vascular system, Cardiopathies: etiologic forms (general aspects and miscellaneous), Cardiovascular, Congenital heart diseases. Malformations of the aorta, pulmonary vessels and vena cava, Cyanotic congenital heart disease, Diseases of red blood cells, Eisenmenger Complex - drug therapy, Eisenmenger Complex - physiopathology, Eisenmenger Complex - psychology, Exercise capacity, Exercise Test - drug effects, Exercise Test - methods, Exercise Tolerance - drug effects, Exercise Tolerance - physiology, Female, Ferrous Compounds - administration & dosage, Follow-Up Studies, Heart, Heart Defects, Congenital - drug therapy, Heart Defects, Congenital - physiopathology, Heart Defects, Congenital - psychology, Hematologic and hematopoietic diseases, Humans, Iron replacement therapy, Male, Medical sciences, Metabolic diseases, Metals (hemochromatosis...), Middle Aged, Other metabolic disorders, Prospective Studies, Quality of life, Quality of Life - psychology, Treatment Outcome