Details

Autor(en) / Beteiligte

• Stewart, Adam
• Wu, Nadine
• Cachat, Jonathan
• Hart, Peter
• Gaikwad, Siddharth
• Wong, Keith
• Utterback, Eli
• Gilder, Thomas
• Kyzar, Evan
• Newman, Alan
• Carlos, Dillon
• Chang, Katie
• Hook, Molly
• Rhymes, Catherine
• Caffery, Michael
• Greenberg, Mitchell
• Zadina, James
• Kalueff, Allan V.

Titel

Pharmacological modulation of anxiety-like phenotypes in adult zebrafish behavioral models

Ist Teil von

• Progress in neuro-psychopharmacology & biological psychiatry, 2011-08, Vol.35 (6), p.1421-1431

Ort / Verlag

England: Elsevier Inc

Erscheinungsjahr

2011

Quelle

MEDLINE

Beschreibungen/Notizen

• Zebrafish ( Danio rerio) are becoming increasingly popular in neurobehavioral research. Here, we summarize recent data on behavioral responses of adult zebrafish to a wide spectrum of putative anxiolytic and anxiogenic agents. Using the novel tank test as a sensitive and efficient behavioral assay, zebrafish anxiety-like behavior can be bi-directionally modulated by drugs affecting the gamma-aminobutyric acid, monoaminergic, cholinergic, glutamatergic and opioidergic systems. Complementing human and rodent data, zebrafish drug-evoked phenotypes obtained in this test support this species as a useful model for neurobehavioral and psychopharmacological research. ► Zebrafish (Danio rerio) is becoming increasingly popular in neurobehavioral research. ► Data on behavioral responses of adult fish to anxiotropic drugs is summarized. ► The novel tank test is sensitive to drug-evoked zebrafish anxiety-like behavior. ► Zebrafish behavioral phenotypes parallel human and rodent data. ► Zebrafish models are a useful tool for neurobehavioral research.