Details

Autor(en) / Beteiligte

• Martinez-Lopez, Joaquin
• Blade, Joan
• Mateos, María-Victoria
• Grande, Carlos
• Alegre, Adrián
• García-Laraña, José
• Sureda, Anna
• de la Rubia, Javier
• Conde, Eulogio
• Martinez, Rafael
• de Arriba, Felipe
• Viguria, Maria C.
• Besalduch, Joan
• Cabrera, Rafael
• Gonzalez-San Miguel, José D.
• Guzman-Zamudio, José Luis
• Gomez del Castillo, Maria Carmen
• Moraleda, José Maria
• García-Ruiz, Juan C.
• San Miguel, Jesús
• Lahuerta, Juan José

Titel

Long-term prognostic significance of response in multiple myeloma after stem cell transplantation

Ist Teil von

• Blood, 2011-07, Vol.118 (3), p.529-534

Ort / Verlag

Washington, DC: Elsevier Inc

Erscheinungsjahr

2011

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• For establishing the true effect of different response categories in patients with multiple myeloma (MM) treated with autologous stem cell transplantation, we evaluated, after a median follow-up of 153 months, 344 patients with MM who received a transplant between 1989 and 1998. Overall survival (OS) at 12 years was 35% in complete response (CR) patients, 22% in near complete response (nCR), 16% in very good partial response (VGPR), and 16% in partial response (PR) groups. Significant differences in OS and progression-free survival were found between CR and nCR groups (P = .01 and P = .002, respectively), between CR and VGPR groups (P = .0001 and P = .003), or between CR and PR groups (P = .003 and P = < 10−5); no differences were observed between the nCR and VGPR groups (P = .2 and P = .9) or between these groups and the PR group (P = .1 and P = .8). A landmark study found a plateau phase in OS after 11 years; 35% patients in the CR group and 11% in the nCR+VGPR+PR group are alive at 17 years; 2 cases had relapsed in the nCR+VGPR+PR group. In conclusion, MM achieving CR after autologous stem cell transplantation is a central prognostic factor. The relapse rate is low in patients with > 11 years of follow-up, possibly signifying a cure for patients in CR.