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The aim of this article paper is to offer a Latin-American perspective on the field of post-colonial studies. Following the modernity/coloniality/de-coloniality approach it is possible to recognize how the complicity between modernity and rationality has worked to homogenize knowledge throughout this part of the world. Such an approach makes it possible to reflect on how this process towards homogeneity has been resisted, as seen in the current indigenous struggles against extractive development policies. These struggles show that the various critiques of development need to be articulated and renewed in order to account for processes such as these, incorporating multiple scales perspectives and knowledge produced from the epistemic colonial difference. The critique of managerialism also needs further developments to account for the new roles of management in contexts of open conflict. It is defended that the re-consideration of Marxist Theory of Dependency could enrich the way we understand global capitalism and that at least part of OS could be liberated from the hegemony of management, opening possibilities for multiple interdisciplinary and intercultural dialogues.