Baillière's best practice & research. Clinical endocrinology & metabolism, 2011-08, Vol.25 (4), p.531-541
2011
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Details
- Autor(en) / Beteiligte
- Titel
- Regulation of vitamin D metabolism
- Ist Teil von
- Baillière's best practice & research. Clinical endocrinology & metabolism, 2011-08, Vol.25 (4), p.531-541
- Ort / Verlag
- Netherlands: Elsevier Ltd
- Erscheinungsjahr
- 2011
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Fundamental to understanding the way in which perturbations in the vitamin D endocrine system can affect human health is an appreciation of the steps involved in the production of the well-recognized active hormonal form, 1,25-dihydroxyvitamin D3 . Thus this paper focuses first on the nature and regulation of the two enzymes responsible for the production of 1,25-dihydroxyvitamin D3 , the 25-hydroxylase in the liver and the 1α-hydroxylase in the kidney. The most important regulators of the 1α-hydroxylase in the kidney are 1,25-dihydroxyvitamin D3 itself, parathyroid hormone and FGF23. The extent and importance of extra-renal, 1,25-dihydroxyvitamin D3 synthesis is then considered. Finally the features of the 24R-hydroxylase, which produces 24R,25-dihydroxyvitamin D3 inthe kidney and is induced by and inactivated, 1,25-dihydroxyvitamin D3 in target cells are described.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1521-690XeISSN: 1878-1594DOI: 10.1016/j.beem.2011.05.003Titel-ID: cdi_crossref_primary_10_1016_j_beem_2011_05_003
- Format
- –
- Schlagworte
- 1,25-dihydroxyvitamin D 3, 24,25-Dihydroxyvitamin D 3 - metabolism, 25-dihydroxyvitamin D 3, 25-hydroxyvitamin D 3, Animals, Autocrine Communication, Calcitriol - metabolism, Cholestanetriol 26-Monooxygenase - genetics, Cholestanetriol 26-Monooxygenase - metabolism, CYP24, CYP24A1, CYP2R1′ CYP27B1, Endocrinology & Metabolism, Feedback, Physiological, fibroblast growth factor 23 (FGF23), Gene Expression Regulation, Enzymologic, Humans, hydroxylase, Kidney - metabolism, Liver - metabolism, metabolism, Paracrine Communication, parathyroid hormone (PTH), Signal Transduction, Steroid Hydroxylases - genetics, Steroid Hydroxylases - metabolism, vitamin D, Vitamin D - metabolism, Vitamin D3 24-Hydroxylase