Details

Autor(en) / Beteiligte

• Chadzynski, Grzegorz L.
• Bender, Benjamin
• Groeger, Adriane
• Erb, Michael
• Klose, Uwe

Titel

Tissue specific resonance frequencies of water and metabolites within the human brain

Ist Teil von

• Journal of magnetic resonance (1997), 2011-09, Vol.212 (1), p.55-63

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2011

Link zum Volltext

Quelle

ScienceDirect

Beschreibungen/Notizen

• [Display omitted] ► There are regional differences in frequency distances between water and metabolites. ► Higher values of frequency distances were reported for gray matter voxels. ► Water to NAA distance showed highest white matter to gray matter differences. ► Unsuppressed spectra can provide an additional information about water signal. Chemical shift imaging (CSI) without water suppression was used to examine tissue-specific resonance frequencies of water and metabolites within the human brain. The aim was to verify if there are any regional differences in those frequencies and to determine the influence of chemical shift displacement in slice-selection direction. Unsuppressed spectra were acquired at 3 T from nine subjects. Resonance frequencies of water and after water signal removal of total choline, total creatine and NAA were estimated. Furthermore, frequency distances between the water and those resonances were calculated. Results were corrected for chemical shift displacement. Frequency distances between water and metabolites were consistent and greater for GM than for WM. The highest value of WM to GM difference (14 ppb) was observed for water to NAA frequency distance. This study demonstrates that there are tissue-specific differences between frequency distances of water and metabolites. Moreover, the influence of chemical shift displacement in slice-selection direction is showed to be negligible.