Details

Autor(en) / Beteiligte

• Wei, Li
• Zhao, Yong
• Guo, Tian-kang
• Li, Pei-qiang
• Wu, Hua
• Xie, Han-bing
• Ma, Ke-jun
• Gao, Feng
• Xie, Xiao-dong

Titel

Association of mtDNA D-Loop Polymorphisms with Risk of Gastric Cancer in Chinese Population

Ist Teil von

• Pathology oncology research, 2011-09, Vol.17 (3), p.735-742

Ort / Verlag

Dordrecht: Springer Netherlands

Erscheinungsjahr

2011

Quelle

MEDLINE

Beschreibungen/Notizen

• The aim of present study was to evaluate the association of common polymorphisms detected in mitochondrial DNA (mtDNA) D-loop region (mononucleotide repetitive D310, single nucleotide polymorphism (SNP) D16521) with susceptibility to gastric cancer (GC) in northwestern Chinese population. A total of 180 GC patients and 218 healthy controls were investigated by using PCR- denaturing high performance liquid chromatography (DHPLC) assay. Genotype and allele distributions and haplotype construction were analyzed in case–control study. We found D310 and D16521 heteroplasmy were significantly different between GC cases and controls ( p  < 0.05), and D16521 homoplasmy showed association with histological grade of GC ( p  < 0.05). Haplotype 7C/T, 8C/C and 9C/C had significant association with GC risk implied from analysis of D310 and D16521. Taken together, these findings suggested that mtDNA D-Loop polymorphisms and haplotypes may contribute to genetic susceptibility to GC in Chinese population.