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Circulating endothelial progenitors and CXCR4‐positive circulating endothelial cells are predictive markers for bevacizumab
Cancer, 2011-09, Vol.117 (17), p.4026-4032
Matsusaka, Satoshi
Mishima, Yuji
Suenaga, Mitsukuni
Terui, Yasuhito
Kuniyoshi, Ryoko
Mizunuma, Nobuyuki
Hatake, Kiyohiko
2011
Details
Autor(en) / Beteiligte
Matsusaka, Satoshi
Mishima, Yuji
Suenaga, Mitsukuni
Terui, Yasuhito
Kuniyoshi, Ryoko
Mizunuma, Nobuyuki
Hatake, Kiyohiko
Titel
Circulating endothelial progenitors and CXCR4‐positive circulating endothelial cells are predictive markers for bevacizumab
Ist Teil von
Cancer, 2011-09, Vol.117 (17), p.4026-4032
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2011
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
BACKGROUND: Bevacizumab plus chemotherapy is a standard option in the treatment of metastatic colorectal cancer (mCRC). The aim of this study was to investigate the potential of circulating endothelial cell progenitors (CEPs) and phenotypical circulating endothelial cells (CECs) as surrogate markers of clinical outcome in mCRC patients to identify responders to bevacizumab in combination with chemotherapy. METHODS: A total of 69 patients with measurable mCRC were enrolled in this prospective study. Whole blood samples were analyzed before initiation of treatment and on days 4 and 14. Phenotypical CECs and CEPs were then isolated and enumerated by using flow cytometry. RESULTS: CEP levels of less than 0.04% on day 4 were significantly associated with longer progression‐free survival (PFS) and overall survival (OS) (P < .001, P = .002, respectively) as compared with levels of 0.04% or more. In addition, CXCR4‐positive CEC levels of less than 20% at baseline were significantly associated with longer PFS and OS as compared other indicators investigated (P < .001, P = .002, respectively). CONCLUSIONS: Levels of CEPs on day 4 and proportion of CXCR4‐positive CECs at baseline were correlated with the prognosis of bevacizumab combination chemotherapy, suggesting that these surrogate markers may play a core role in the selection of candidates for bevacizumab treatment. Cancer 2011;. © 2011 American Cancer Society. Levels of circulating endothelial progenitors on day 4 and the proportion of CXCR4‐positive circulating endothelial cells at baseline were correlated with the prognosis of bevacizumab combination chemotherapy, suggesting that these surrogate markers may play a core role in the selection of candidates for bevacizumab treatment.
Sprache
Englisch
Identifikatoren
ISSN: 0008-543X
eISSN: 1097-0142
DOI: 10.1002/cncr.25977
Titel-ID: cdi_proquest_miscellaneous_884847177
Format
–
Schlagworte
Adult
,
Aged
,
Angiogenesis Inhibitors - therapeutic use
,
Antibodies, Monoclonal - therapeutic use
,
Antibodies, Monoclonal, Humanized
,
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
,
Bevacizumab
,
Biological and medical sciences
,
Biomarkers, Tumor - blood
,
Cancer
,
Chemotherapy
,
circulating endothelial progenitors
,
Colorectal cancer
,
Colorectal carcinoma
,
Colorectal Neoplasms - blood
,
Colorectal Neoplasms - drug therapy
,
Colorectal Neoplasms - mortality
,
Colorectal Neoplasms - pathology
,
CXCR4 protein
,
CXCR4‐positive circulating endothelial cells
,
Disease-Free Survival
,
Endothelial cells
,
Endothelial Cells - metabolism
,
Female
,
Flow cytometry
,
Fluorouracil - therapeutic use
,
Gastroenterology. Liver. Pancreas. Abdomen
,
Humans
,
Leucovorin - therapeutic use
,
Male
,
Medical prognosis
,
Medical sciences
,
Metastases
,
metastatic colorectal cancer
,
Middle Aged
,
Neoplasm Metastasis
,
Organoplatinum Compounds - therapeutic use
,
Patients
,
Progenitor cells
,
Prognosis
,
Receptors, CXCR4 - metabolism
,
Stem Cells
,
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
,
Survival
,
Treatment Outcome
,
Tumors
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