Details

Autor(en) / Beteiligte

• Marchant, Barrie K.
• Reimherr, Fred W.
• Halls, Corinne
• Williams, Erika D.
• Strong, Robert E.
• Kondo, Douglas
• Soni, Poonam
• Robison, Reid J.

Titel

Long-term open-label response to atomoxetine in adult ADHD: influence of sex, emotional dysregulation, and double-blind response to atomoxetine

Ist Teil von

• Attention deficit and hyperactivity disorders, 2011-09, Vol.3 (3), p.237-244

Ort / Verlag

Vienna: Springer Vienna

Erscheinungsjahr

2011

Quelle

MEDLINE

Beschreibungen/Notizen

• A three-year open-label study of atomoxetine in adults with ADHD followed two multicenter, double-blind trials. In the double-blind trials, female gender and higher levels of emotional symptoms were associated with better outcome. Following a 4-week placebo washout period, 384 (of 536) subjects continued into the open-label study. 61% of subjects entering this open-label study remained after 6 months at an average dose of 100 mg/day. Subjects who had previously responded to double-blind atomoxetine achieved maximum response after 8 weeks of open-label medication, but others continued to improve for 36 weeks. Women improved more (7.7 ± 6.4) than men (6.1 ± 6.4) on the Wender–Reimherr Adult Attention Deficit Disorder Scale (WRAADDS) ( P  = .007) and the Conners’ Adult ADHD Rating Scale ( P  = .03). Subjects with emotional dysregulation improved more than others on the WRAADDS ( P  = .001). Responders ultimately improved approximately 60% in attentional, hyperactive/impulsive, and emotional symptoms. Thirty-nine percent of atomoxetine double-blind non-responders became responders during open-label treatment.