Details

Autor(en) / Beteiligte

• Hardie, Andrew D
• Kizziah, Michael K
• Boulter, Daniel J

Titel

Diagnostic accuracy of diffusion-weighted MRI for identifying hepatocellular carcinoma with liver explant correlation

Ist Teil von

• Journal of medical imaging and radiation oncology, 2011-08, Vol.55 (4), p.362-367

Ort / Verlag

Melbourne, Australia: Blackwell Publishing Asia

Erscheinungsjahr

2011

Quelle

Wiley-Blackwell Journals

Beschreibungen/Notizen

• Background: The goal of this study was to use liver explant correlation to assess the diagnostic accuracy of diffusion‐weighted (DW)‐MRI for hepatocellular carcinoma (HCC). Materials and methods: Thirty‐seven patients were retrospectively identified who had undergone liver transplantation and had preoperative, respiratory‐triggered, single‐shot echo‐planar DW‐MRI. Two independent blinded observers evaluated the DW‐MRI images for HCC and comparison was made with the explanted specimens. Results: By pathology, 29 HCCs (mean largest diameter 2.0 cm; range 0.7–4.0 cm) were identified in 20 patients. Sensitivity and specificity for reader 1 were 55 and 92%, and for reader 2 were 45 and 100%. There was ‘substantial’ inter‐observer agreement (kappa = 0.64). Conclusion: DW‐MR is not sensitive enough for HCC to be used as a stand‐alone sequence, although its high specificity suggests that it is likely valuable as a component of a liver MRI protocol.