Details

Autor(en) / Beteiligte

• Kim, Y.J
• Yoon, J.H
• Kim, S.I
• Hong, K.W
• Kim, J.I
• Choi, J.Y
• Yoon, S.K
• You, Y.K
• Lee, M.D
• Moon, I.S
• Kim, D.G
• Kang, M.W

Titel

High Mortality Associated With Acinetobacter Species Infection in Liver Transplant Patients

Ist Teil von

• Transplantation proceedings, 2011-07, Vol.43 (6), p.2397-2399

Ort / Verlag

Amsterdam: Elsevier Inc

Erscheinungsjahr

2011

Quelle

MEDLINE

Beschreibungen/Notizen

• Abstract Background Acinetobacter species have become increasingly important nosocomial pathogens worldwide and can result in a wide range of infections, including bacteremia, pneumonia, urinary tract infection, peritonitis, among others. The aim of this study was to investigate clinical characteristics, mortality, and outcomes among liver transplant recipients with Acinetobacter species infections. Methods We retrospectively analyzed 451 subjects who had undergone living donor liver transplantations between January 2001 and May 2010. Pandrug-resistant (PDR) Acinetobacter species were defined as resistant to all commercially available antibiotics except colistin. Results Infectious complications due to Acinetobacter species appeared in 26 patients (5.8%) with a total of 37 episodes. Of the species identified, 34 were Acinetobacter baumannii and 3 Acinetobacter Iwoffiii . The presumed sources of infection were the biliary tract ( n = 21, 56.8%), lung ( n = 7, 18.9%), intra-abdomen ( n = 6, 16.2%), catheter ( n = 2, 5.4%), and urinary tract ( n = 1, 3.6%). Among the 37 Acinetobacter species, 75.7% (28/37) were PDR species. Age, duration of intensive care unit stay, Child-Pugh score, and Model for End-stage Liver Disease score were not significant risk factors for Acinetobacter species infection. However, the overall mortality among patients with Acinetobacter species infections was 50% (13/26), which was significantly higher than that among those free of infection (50% vs 11.5%, P < .05). Multivariate analysis using a Cox regression model showed that inappropriate antimicrobial treatment was a significant independent risk factor for mortality among patients with Acinetobacter species infections (hazard Ratio = 4.19, 95% confidence interval 1.1–18.7; P = .06). Conclusion Patients with Acinetobacter species infections after liver transplantation show a significantly worse prognosis. PDR Acinetobacter species have been a major problem in our center.